ReviewIranian endodontic journal2022
Regenerative Endodontics Success Factors and their Overall Effectiveness: An Umbrella Review.
Review in Iranian endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 14 citations in OpenAlex.
- Clinical, radiographic, and biomarker perspectives of low-level laser therapy during regenerative endodontic procedures in necrotic immature young teeth: a randomized clinical study.Lasers in medical science · 2025Trial
- Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment.International endodontic journal · 2026Observational
- Article
- Antibiotic approaches to endodontic regeneration.Biomaterial investigations in dentistry · 2026Review
- Stress in Immature Incisor Treated With Regenerative Endodontics or Restored With Bulk-Fill Resin Composite: A 2D Finite Element Analysis.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2025Article
- Evaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis.Restorative dentistry & endodontics · 2025Article
- The Impact of Vital Pulp Therapy on Normal Root Development in Immature Teeth: A Case Report.Iranian endodontic journal · 2025Article
- Nonsurgical Endodontic Treatment of Type IIIa Dens Invaginatus in an Immature Maxillary Central Incisor: A Case Report.Iranian endodontic journal · 2025Article
- Revascularization of an Immature Three Rooted First Mandibular Molar Using Concentrated Growth Factor: A Case Report.Iranian endodontic journal · 2025Article
- Endodontic characteristics of mandibular premolar with dens evaginatus: a retrospective study.Restorative dentistry & endodontics · 2024Article
- Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects.Journal of conservative dentistry and endodontics · 2024Review
- Comparison of the removal of intracanal medicaments used in regenerative endodontics from root canal system using needle, ultrasonic, sonic, and laser-activated irrigation systems.Lasers in medical science · 2024Article
- Management Strategies for Immature Teeth with Pulp Necrosis: An Umbrella Review of Systematic Reviews.Iranian endodontic journal · 2024Review
- Success of Nonsurgical Endodontically Treated Posterior Teeth with Complex Restorative/Prosthodontic Treatments: A Retrospective Study.Iranian endodontic journal · 2024Article
- Unlocking the Potential of Cellular Guidance in Endodontics: Advancing the Process of Pulp Regeneration and Beyond.Cureus · 2024Review
- Effect of different chelators on the push-out bond strength of hydraulic cements in retrograde obturation.Journal of dental research, dental clinics, dental prospects · 2024Article
- Pulp Canal Obliteration Following Traumatic Dental Injury in an Upper Lateral Incisor: A Case Report with 3-year Follow-up.Iranian endodontic journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Regenerative endodontics is a developing field of dentistry and aims to recover the physiological and anatomical functions of the tooth for cases of severe dental caries, pulpal pathologies and dental trauma. Materials and Methods: This umbrella review seeks to discover the scientific evidence on the effectiveness and the factors result in successful regenerative endodontic therapies in teeth with necrotic pulps and with incomplete root development. The study was conducted following the PRISMA Guidelines. There were no restrictions regarding search period. A comprehensive literature search was carried out in EMBASE, LILACS, PubMed, Cochrane, Scopus, and Google Scholar. A quality evaluation was conducted by using AMSTAR-2. A descriptive analysis of the included systematic reviews and meta-analysis were conducted. Results: Thirteen descriptive systematic reviews and 7 meta-analyses were included. Three articles evidenced low methodological quality according to AMSTAR-2 tool. Overall success rates for the endodontic regeneration procedures ranged from 50% to 98% and the survival rates were between 94% and 100%. Pulp regeneration had a high success rate, evidenced by factors such as the resolution of symptoms, healing, increased root length, dentin thickening and recovery of sensitivity. Follow-up varied from 1 to 48 months for the original studies included in the systematic reviews and meta-analyses. Conclusions: Endodontic practice offers the clinician a good treatment option in case of necrotic pulp with immature roots such as the endodontic regeneration, that is supported by high and moderate quality scientific literature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.