ArticleFrontiers in pain research (Lausanne, Switzerland)2022
Investigations into an overlooked early component of painful nociceptive withdrawal reflex responses in humans.
Article in Frontiers in pain research (Lausanne, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Discovery of a peripherally restricted αCell reports. Medicine · 2026Article
- Coding of mechanical pain by myelinated and unmyelinated nociceptors in human hairy skin.Pain reports · 2026Article
- Making sense of feelings.Neuroscience of consciousness · 2024Article
- Article
- PIEZO2-dependent rapid pain system in humans and mice.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: The role of pain as a warning system necessitates a rapid transmission of information from the periphery for the execution of appropriate motor responses. The nociceptive withdrawal reflex (NWR) is a physiological response to protect the limb from a painful stimulus and is often considered an objective measure of spinal nociceptive excitability. The NWR is commonly defined by its latency in the presumed A Methods: We revisited our earlier work on NWR measurements in which, following convention, only reflex responses in the presumed A Results: In both cohorts, we found an abundance of recordings with short-latency reflex responses. In nearly 90% of successful recordings, only single reflex responses (not dual) were seen which allowed us to compare pain ratings based on reflex latencies. We found that shorter latency reflexes were just as painful as those in the conventional latency range. Conclusion: We found a preponderance of short-latency painful reflex responses. Based on this finding, we suggest that short-latency responses must be considered in future studies. Whether these are signaled by the ultrafast nociceptors remains to be determined.
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