Evidence map›Paper›PMID 36703917›Full record

ArticleFrontiers in molecular biosciences2022

Salivary protein kinase C alpha and novel microRNAs as diagnostic and therapeutic resistance markers for oral squamous cell carcinoma in Indian cohorts.

Sheetanshu Saproo, Shashanka S Sarkar, Vishakha Gautam, Chingmei W Konyak, Gouri Dass, Arpita Karmakar, Mansi Sharma, Gaurav Ahuja, Anand Gupta, Juhi Tayal and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. [Research progress on the mechanisms of resistance to cetuximab targeted therapy in head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  2. Article
  3. Review
  4. The prognostic role of salivary miRNAs in oral squamous cell carcinoma: technical challenges and clinical perspectives.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Sheetanshu SaprooDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Shashanka S SarkarDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Vishakha GautamDepartment of Computational Biology, Indraprastha Institute of Information Technology- Delhi (IIIT-Delhi), New Delhi, India.
Chingmei W KonyakDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Gouri DassDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Arpita KarmakarDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Mansi SharmaDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Gaurav AhujaDepartment of Computational Biology, Indraprastha Institute of Information Technology- Delhi (IIIT-Delhi), New Delhi, India.
Anand GuptaDepartment of Dentistry, Government Medical College and Hospital, Chandigarh, India.
Juhi TayalRajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Anurag MehtaRajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Srivatsava NaiduDepartment of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Indian Institute of Technology Ropar · INRajiv Gandhi Cancer Institute and Research Centre · INGovernment Medical College and Hospital · INIndian Institute of Technology Delhi · INIndraprastha Institute of Information Technology Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is the second leading cause of cancer-related morbidity and mortality in India. Tobacco, alcohol, poor oral hygiene, and socio-economic factors remain causative for this high prevalence. Identification of non-invasive diagnostic markers tailored for Indian population can facilitate mass screening to reduce overall disease burden. Saliva offers non-invasive sampling and hosts a plethora of markers for OSCC diagnosis. Here, to capture the OSCC-specific salivary RNA markers suitable for Indian population, we performed RNA-sequencing of saliva from OSCC patients (

Indexed as

liquid biospsynon-invasive diagnosticsoral microbiotaoral squamous cell carcinoma (OSCC)salivary RNAs

Identifiers

PMID36703917
PMCPMC9871261
OpenAlexW4315489679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.