ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2024
Threat Memory in the Sensory Cortex: Insights from Olfaction.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Spatial segregation of piriform output neurons toward cognitive and emotional networks.PNAS nexus · 2026Article
- Amygdala subregion MRI alterations in Parkinson's disease correlate with olfactory function.Frontiers in aging neuroscience · 2026Article
- Trait-like visual cortical hyperactivity in trait anxiety.Nature communications · 2025Article
- Anxious vision: Trait-like visual cortical hyperactivity in trait anxiety.bioRxiv : the preprint server for biology · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Second-order threat conditioning in the amygdala-posterior piriform cortex network.Communications biology · 2025Article
- Characterizing Olfactory Brain Responses in Young Infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Independence Threat or Interdependence Threat? The Focusing Effect on Social or Physical Threat Modulates Brain Activity.Brain sciences · 2024Article
- Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Correlational patterns of neuronal activation and epigenetic marks in the basolateral amygdala and piriform cortex following olfactory threat conditioning and extinction in rats.Frontiers in molecular neuroscience · 2024Article
- Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.Biology · 2023Review
- Sensing fear: fast and precise threat evaluation in human sensory cortex.Trends in cognitive sciences · 2023Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The amygdala has long held the center seat in the neural basis of threat conditioning. However, a rapidly growing literature has elucidated extra-amygdala circuits in this process, highlighting the sensory cortex for its critical role in the mnemonic aspect of the process. While this literature is largely focused on the auditory system, substantial human and rodent findings on the olfactory system have emerged. The unique nature of the olfactory neuroanatomy and its intimate association with emotion compels a review of this recent literature to illuminate its special contribution to threat memory. Here, integrating recent evidence in humans and animal models, we posit that the olfactory (piriform) cortex is a primary and necessary component of the distributed threat memory network, supporting mnemonic ensemble coding of acquired threat. We further highlight the basic circuit architecture of the piriform cortex characterized by distributed, auto-associative connections, which is prime for highly efficient content-addressable memory computing to support threat memory. Given the primordial role of the piriform cortex in cortical evolution and its simple, well-defined circuits, we propose that olfaction can be a model system for understanding (transmodal) sensory cortical mechanisms underlying threat memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.