ArticleCommunications chemistry2020
Dual sequence definition increases the data storage capacity of sequence-defined macromolecules.
Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sequence-Controlled Copolymers Through Selective Ring-Opening Polymerization of Multiunit Macrolactones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Highly robust molecular information carriers for traceability of plastic materials.Nature communications · 2026Article
- Circularity in Sequence-Controlled Copolyamides Enabled by Regioselective Enzymatic Hydrolysis.Journal of the American Chemical Society · 2026Article
- A Modular Synthetic Strategy toward Fast-Growing Poly(amide-carbosilane) Dendrimers Based on Click Chemistry and Organic Solvent Nanofiltration.ACS polymers Au · 2026Article
- Article
- Multistate Dihydroazulene-Spiropyran Dyads: Path-Dependent Switchings and Refinement of the "Meta-rule" of Photoactivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nondestructive Sequencing of Enantiopure Oligoesters by Nuclear Magnetic Resonance Spectroscopy.JACS Au · 2022Article
- Molecular Encryption and Steganography Using Mixtures of Simultaneously Sequenced, Sequence-Defined Oligourethanes.ACS central science · 2022Article
- Molecular data storage with zero synthetic effort and simple read-out.Scientific reports · 2022Article
- Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Reading mixtures of uniform sequence-defined macromolecules to increase data storage capacity.Communications chemistry · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Sequence-defined macromolecules offer applications in the field of data storage. Challenges include synthesising precise and pure sequences, reading stored information and increasing data storage capacity. Herein, the synthesis of dual sequence-defined oligomers and their application for data storage is demonstrated. While applying the well-established Passerini three-component reaction, the degree of definition of the prepared monodisperse macromolecules is improved compared to previous reports by utilising nine specifically designed isocyanide monomers to introduce backbone definition. The monomers are combined with various aldehyde components to synthesise dual-sequence defined oligomers. Thus, the side chains and the backbones of these macromolecules can be varied independently, exhibiting increased molecular diversity and hence data storage capacity per repeat unit. In case of a dual sequence-defined pentamer, 33 bits are achieved in a single molecule. The oligomers are obtained in multigram scale and excellent purity. Sequential read-out by tandem ESI-MS/MS verifies the high data storage capacity of the prepared oligomers per repeat unit in comparison to other sequence defined macromolecules.
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Registered trials
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