ArticleCommunications chemistry2020
Direct ring-strain loading for visible-light accelerated bioorthogonal ligation via diarylsydnone-dibenzo[b,f ][1,4,5]thiadiazepine photo-click reactions.
Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Tunable Cell Surface Proximity Labeling via Photocatalytic and Enzymatic Activation of Fast Bioorthogonal Chemistry.Journal of the American Chemical Society · 2026Article
- Synergistic Two-Color Photochemical Polymer Network Formation and Lithography.Angewandte Chemie (International ed. in English) · 2025Article
- Photo-Triggerable Polymerization and Depolymerization of Stiff-Stilbene Lactones.Journal of the American Chemical Society · 2025Article
- Covalent chemical probes.Communications chemistry · 2025Article
- Visible and near-infrared light-induced photoclick reactions.Nature reviews. Chemistry · 2024Review
- With or without a co-solvent? highly efficient ultrafast phenanthrenequinone-electron rich alkene (PQ-ERA) photoclick reactions.Chemical science · 2024Article
- Photo-activatable Reagents for Bioorthogonal Ligation Reactions.Topics in current chemistry (Cham) · 2023Review
- Photoswitchable and long-lived seven-membered cyclic singlet diradicals for the bioorthogonal photoclick reaction.Chemical science · 2023Article
- Establishing PQ-ERA photoclick reactions with unprecedented efficiency by engineering of the nature of the phenanthraquinone triplet state.Chemical science · 2023Article
- Ligand-Directed Photocatalysts and Far-Red Light Enable Catalytic Bioorthogonal Uncaging inside Live Cells.Journal of the American Chemical Society · 2023Article
- Fluorescence turn-on by photoligation - bright opportunities for soft matter materials.Chemical science · 2022Review
- Seeking Citius: Photochemical Access of Reactive Intermediates for Faster Bioorthogonal Reactions.Chembiochem : a European journal of chemical biology · 2022Article
- Expanding the functionality of proteins with genetically encoded dibenzo[Chemical science · 2022Article
- Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light.Journal of the American Chemical Society · 2022Article
- EnablingJournal of the American Chemical Society · 2021Article
- Photoclick Chemistry: A Bright Idea.Chemical reviews · 2021Review
- Light-Triggered Click Chemistry.Chemical reviews · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Ultra-fast and selective covalent-bond forming reactions with spatiotemporal controllability are foundational for developing a bioorthogonal approach with high manipulability. However, it is challenging to exploit a reporter functional group to achieve these requirements simultaneously. Here, 11H-Dibenzo[c,f][1,2]diazepine and a set of heterocyclic analogues are investigated for both their photo-switching natures and their ability to serve as dipolarophiles in photo-click reactions with diarylsydnone. Sulfur-containing dibenzothiadiazepine (DBTD) is discovered to be an excellent chemical reporter in cycloaddition with visible-light excitation for in-situ ring-strain loading via its (Z) → (E) photo-isomerization. The bioorthogonal utility of the DBTD tag in spatiotemporally controlled ligation for protein modifications on live cells is also demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.