ArticleCommunications chemistry2020
Non-aqueous, zwitterionic solvent as an alternative for dimethyl sulfoxide in the life sciences.
Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed.
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- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- The impact of initial cooling rates on cell preservation in frozen water-dimethyl sulfoxide media: a morphological study.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Isomeric 3-Pyridinylmethylcoumarins Differ in Erk1/2-Inhibition and Modulation of BV2 Microglia-Mediated Neuroinflammation.Molecules (Basel, Switzerland) · 2025Article
- Overcoming ice: cutting-edge materials and advanced strategies for effective cryopreservation of biosample.Journal of nanobiotechnology · 2025Review
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- Developing a transcatheter injectable nanoclay- alginate gel for minimally invasive procedures.Journal of the mechanical behavior of biomedical materials · 2024Article
- Cell-compatible isotonic freezing media enabled by thermo-responsive osmolyte-adsorption/exclusion polymer matrices.Communications chemistry · 2023Article
- The potential of phenothiazinium dyes as cytotoxicity markers in cisplatin-treated cells.Scientific reports · 2023Article
- Fluorinated Human Serum Albumin as PotentialMolecules (Basel, Switzerland) · 2023Article
- Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant.Scientific reports · 2023Article
- Novel adult cortical neuron processing and screening method illustrates sex- and age-dependent effects of pharmaceutical compounds.Scientific reports · 2022Article
- Antifungal Activity of Beluntas "Indian Camphorweed" (Pluchea indica) Ethanol Extract on Candida albicans In Vitro Using Different Solvent Concentrations.European journal of dentistry · 2022Article
- Cryostorage of unstableRSC advances · 2022Article
- Synthetic zwitterions as efficient non-permeable cryoprotectants.Communications chemistry · 2021Article
- Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example.Molecules (Basel, Switzerland) · 2021Article
- Nylon 6 Nanofiber Web-Based Signal Transmission Line Treated with PEDOT:PSS and DMSO Treatment.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Dimethyl sulfoxide (DMSO) is widely used as a solvent in the life sciences, however, it is somewhat toxic and affects cell behaviours in a range of ways. Here, we propose a zwitterionic liquid (ZIL), a zwitterion-type ionic liquid containing histidine-like module, as a new alternative to DMSO. ZIL is not cell permeable, less toxic to cells and tissues, and has great potential as a vehicle for various hydrophobic drugs. Notably, ZIL can serve as a solvent for stock solutions of platinating agents, whose anticancer effects are completely abolished by dissolution in DMSO. Furthermore, ZIL possesses suitable affinity to the plasma membrane and acts as a cryoprotectant. Our results suggest that ZIL is a potent, multifunctional and biocompatible solvent that compensates for many shortcomings of DMSO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.