Evidence map›Paper›PMID 36703387›Full record

ArticleCommunications chemistry2020

Unforeseen crystal forms of the natural osmolyte floridoside.

Andrew J Maneffa, Adrian C Whitwood, A Steve Whitehouse, Hugh Powell, James H Clark, Avtar S Matharu

Open access · goldAbstract read
In one paragraph

Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew J ManeffaGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Adrian C WhitwoodDepartment of Chemistry, University of York, Heslington, York, YO10 5DD, UK.ORCID http://orcid.org/0000-0002-5132-5468
A Steve WhitehouseNestlé Product Technology Centre (Nestec York Ltd.), Clifton, York, YO31 8FY, UK.
Hugh PowellNestlé Product Technology Centre (Nestec York Ltd.), Clifton, York, YO31 8FY, UK.
James H ClarkGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Avtar S MatharuGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. avtar.matharu@york.ac.uk.ORCID http://orcid.org/0000-0002-9488-565X
University of York · GBNestlé (United Kingdom) · GB

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P504919/1
6 · The paper itself

Abstract

Floridoside (2-α-O-D-galactopyranosyl glycerol) is a glycerol glycoside that is biosynthesised by most species of red algae and has been implicated as an intracellular regulator of various homeostatic functions. Here, we report the identification of two unforeseen crystal forms of the ubiquitous natural osmolyte floridoside including a seemingly unheralded second anhydrous conformational polymorph and the unambiguous description of an elusive monohydrated variant. By employing a variety of thermal and spectroscopic techniques, we begin to explore both their macro and molecular physicochemical properties, which are notably different to that of the previously reported polymorph. This work advances the characterisation of this important natural biomolecule which could aid in facilitating optimised utilisation across a variety of anthropocentric applications and improve comprehension of its role in-vivo as a preeminent compatible solute.

Identifiers

PMID36703387
PMCPMC9814874
OpenAlexW3086067183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.