ArticleCommunications chemistry2020
Transient domains of ordered water induced by divalent ions lead to lipid membrane curvature fluctuations.
Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Second harmonic imaging of membrane potentials: Comparing water and chromophores as probes.Biophysical journal · 2026Article
- Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes.Journal of the American Chemical Society · 2024Article
- Binding-induced lipid domains: Peptide-membrane interactions with PIPBiophysical journal · 2024Article
- The reproduction process of Gram-positive protocells.Scientific reports · 2024Article
- Deciphering Density Fluctuations in the Hydration Water of Brownian Nanoparticles via Upconversion Thermometry.The journal of physical chemistry letters · 2024Article
- Passive transport of CaBiophysical journal · 2023Article
- Ion-Induced Transient Potential Fluctuations Facilitate Pore Formation and Cation Transport through Lipid Membranes.Journal of the American Chemical Society · 2022Article
- Voltage-Driven Alterations to Neuron Viscoelasticity.Bioelectricity · 2022Article
- Lipid Melting Transitions Involve Structural Redistribution of Interfacial Water.The journal of physical chemistry. B · 2021Article
- Mechanical Principles Governing the Shapes of Dendritic Spines.Frontiers in physiology · 2021Article
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Authors and funding
4 authors.
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Abstract
Cell membranes are composed of a hydrated lipid bilayer that is molecularly complex and diverse, and the link between molecular hydration structure and membrane macroscopic properties is not well understood, due to a lack of technology that can probe and relate molecular level hydration information to micro- and macroscopic properties. Here, we demonstrate a direct link between lipid hydration structure and macroscopic dynamic curvature fluctuations. Using high-throughput wide-field second harmonic (SH) microscopy, we observe the formation of transient domains of ordered water at the interface of freestanding lipid membranes. These domains are induced by the binding of divalent ions and their structure is ion specific. Using nonlinear optical theory, we convert the spatiotemporal SH intensity into maps of membrane potential, surface charge density, and binding free energy. Using an electromechanical theory of membrane bending, we show that transient electric field gradients across the membrane induce spatiotemporal membrane curvature fluctuations.
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