Direct N-substituted N-thiocarboxyanhydride polymerization towards polypeptoids bearing unprotected carboxyl groups.

Botuo Zheng, Tianwen Bai, Jun Ling, Jihong Sun

Abstract read

In one paragraph

Article in Communications chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A Field Guide to Optimizing Peptoid Synthesis.ACS polymers Au · 2022
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5 · Who and what money

Authors and funding

4 authors.

Botuo ZhengDepartment of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.

Tianwen BaiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Jun LingMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. lingjun@zju.edu.cn.ORCID http://orcid.org/0000-0002-0365-1381

Jihong SunDepartment of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. sunjihong@zju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21674091National Natural Science Foundation of China (National Science Foundation of China) 81871403National Natural Science Foundation of China (National Science Foundation of China) 81971600

6 · The paper itself

Abstract

Synthesis of poly(α-amino acid)s bearing carboxyl groups is a critical pathway to prepare biomaterials to simulate functional proteins. The traditional approaches call for carboxyl-protected monomers to prevent degradation of monomers or wrong linkage. In this contribution, we synthesize N-carboxypentyl glycine N-thiocarboxyanhydride (CPG-NTA) and iminodiacetic acid N-thiocarboxyanhydride (IDA-NTA) without protection. Initiated by amines, CPG-NTA directly polymerizes into polyCPG bearing unprotected carboxyl groups with controlled molecular weight (2.8-9.3 kg mol

Identifiers

PMID36703352

DOI10.1038/s42004-020-00393-y

PMCPMC9814353

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