Evidence map›Paper›PMID 36703244›Full record

ArticleAging cell2023

Age-related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L-type calcium channel, Ca

Shannon J Moore, Victor A Cazares, Stephanie J Temme, Geoffrey G Murphy

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The Impact of Overexpression of the Mouse Ortholog ofBiological psychiatry global open science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Shannon J MooreMichigan Neuroscience Institute, Ann Arbor, Michigan, USA.ORCID 0000-0002-5874-6572
Victor A CazaresMolecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6625-7103
Stephanie J TemmeMichigan Neuroscience Institute, Ann Arbor, Michigan, USA.ORCID 0000-0002-7845-0955
Geoffrey G MurphyMichigan Neuroscience Institute, Ann Arbor, Michigan, USA.ORCID 0000-0003-3691-1722
University of Michigan · USMichigan Medicine · USWilliams College · US

Funding

Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
Neural Stem Cell Transplantation: A Novel Cellular Therapy for Alzheimer's DiseaseU01AG057562 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE, MURPHY, GEOFFREY G · 2018 to 2020
$3.5M
The Role of PAI-1 in Cerebral Microvascular Dysfunction and the Development of Alzheimer’s Disease NeuropathologyR01AG074552 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A, MURPHY, GEOFFREY G · 2021 to 2025
$3.4M
Novel Imaging Biomarker for Treating Spatial Memory Loss in Prodromal Alzheimer's Disease ModelsR01AG058171 · NIA · WAYNE STATE UNIVERSITY · PI BENNETT, BRIAN M, BERKOWITZ, BRUCE A. · 2017 to 2021
$2.8M
Testing the Calcium Hypothesis of Age-related Cognitive DeclineR01AG052934 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, GEOFFREY G · 2016 to 2020
$2.1M
NIA NIH HHS R01 AG052934NIA NIH HHS R01 AG058171NIA NIH HHS R01 AG074552NIA NIH HHS U01 AG057562NIGMS NIH HHS K12 GM111725
6 · The paper itself

Abstract

The calcium dysregulation hypothesis of brain aging posits that an age-related increase in neuronal calcium concentration is responsible for alterations in a variety of cellular processes that ultimately result in learning and memory deficits in aged individuals. We previously generated a novel transgenic mouse line, in which expression of the L-type voltage-gated calcium, Ca

Indexed as

CalciumCalcium Channels, L-TypeAnimalsCognitionLearningMaze LearningMiceMice, Inbred C57BLMice, TransgenicCalciumCalcium Channels, L-Typeafterhyperpolarizationfear generalizationlearning and memorymousenovel object recognition

Identifiers

PMID36703244
PMCPMC10014069
OpenAlexW4318263329

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read58
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.