Evidence map›Paper›PMID 36703217›Full record

Observational studyJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2023

Development and validation of the modified index of fragility in head and neck cancer surgery.

Koorosh Semsar-Kazerooni, Keith Richardson, Véronique-Isabelle Forest, Alex Mlynarek, Michael P Hier, Nader Sadeghi, Marco A Mascarella

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Koorosh Semsar-KazerooniFaculty of Medicine, McGill University, Montréal, QC, Canada. Koorosh.semsar-kazerooni@mail.mcgill.ca.ORCID http://orcid.org/0000-0002-1486-0314
Keith RichardsonDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
Véronique-Isabelle ForestDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
Alex MlynarekDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
Michael P HierDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
Nader SadeghiDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
Marco A MascarellaDepartment of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montréal, QC, Canada.
McGill University Health Centre · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to develop and validate, a clinically useful modified index of fragility (mIFG) to identify patients at risk of fragility and to predict postoperative adverse events.

methodAn observational study was performed using the American College of Surgeons National Surgical Quality Improvement Program database, from 2006 to 2018. All patients undergoing nonemergency head and neck cancer surgery were included. A seven-item index (mIFG) was developed using variables associated with frailty, cachexia, and sarcopenia, drawn from the literature (weight loss, low body mass index, dyspnea, diabetes, serum albumin, hematocrit, and creatinine). Multivariable logistic regression was used to model the association between mIFG, postoperative adverse events and death. A validation cohort was then used to ascertain the diagnostic accuracy of the mIFG.

resultsA total of 23,438 cases were included (16,407 in the derivation group and 7031 in the validation group). There was a total of 4273 postoperative major adverse events (AE) and deaths, 1023 postoperative pulmonary complications and 1721 wound complications. Using the derivation cohort, the 7-item mIFG was independently associated with death, major AEs, pulmonary and wound complications, when controlling for significant covariates. The mIFG predicted death and major adverse events using the validation cohort with an accuracy of 0.70 (95% CI: 0.63-0.76) and 0.64 (95% CI: 0.63-0.66), respectively. The mIFG outperformed the modified Frailty index.

conclusionThe modified index of fragility is a reliable and easily accessible tool to predict risk of postoperative adverse events and death in patients undergoing head and neck cancer surgery.

Indexed as

FrailtyHead and Neck NeoplasmsHumansLogistic ModelsPostoperative ComplicationsQuality ImprovementRetrospective StudiesRisk AssessmentRisk FactorsCachexiaFrailtyHead and neck neoplasmsModified index of fragilitySarcopenia

Identifiers

PMID36703217
PMCPMC9878788
OpenAlexW4318067775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.