Evidence map›Paper›PMID 36702970›Full record

ArticleActa neurochirurgica2023

Up-front single-session radiosurgery for large brain metastases-volumetric responses and outcomes.

Carolina Benjamin, Jason Gurewitz, Aya Nakamura, Monica Mureb, Reed Mullen, Donato Pacione, Joshua Silverman, Douglas Kondziolka

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In one paragraph

Article in Acta neurochirurgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolina BenjaminDepartment of Neurosurgery, University of Miami Health System, 1095 N.W. 14Th Terrace, 2Nd Floor, Miami, FL, 33136, USA. Carolina.benjamin@med.miami.edu.ORCID http://orcid.org/0000-0001-8134-7943
Jason GurewitzDepartment of Radiation Oncology, NYU Langone Medical Center, New York, NY, USA.
Aya NakamuraDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
Monica MurebDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
Reed MullenDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
Donato PacioneDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
Joshua SilvermanDepartment of Radiation Oncology, NYU Langone Medical Center, New York, NY, USA.
Douglas KondziolkaDepartment of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients presenting with large brain metastases (LBM) pose a management challenge to the multidisciplinary neuro-oncologic team. Treatment options include surgery, whole-brain or large-field radiation therapy (WBRT), stereotactic radiosurgery (SRS), or a combination of these.

objectiveTo determine if corticosteroid therapy followed by SRS allows for efficient minimally invasive care in patients with LBMs not compromised by mass effect.

methodsWe analyzed the change in tumor volume to determine the efficacy of single-session SRS in the treatment of LBM in comparison to other treatment modalities. Twenty-nine patients with systemic cancer and brain metastasis (≥ 2.7 cm in greatest diameter) who underwent single-session SRS were included.

resultsAmong 29 patients, 69% of patients had either lung, melanoma, or breast cancer. The median initial tumor size (maximal diameter) was 32 mm (range 28-43), and the median initial tumor volume was 9.56 cm

conclusionInitial high-dose corticosteroid therapy followed by prompt single-stage SRS is a safe and efficacious method to manage patients with LBMs (defined as ≥ 2.7 cm).

Indexed as

Brain NeoplasmsMelanomaRadiosurgeryAdrenal Cortex HormonesHumansRetrospective StudiesTreatment OutcomeAdrenal Cortex HormonesGamma Knife radiosurgeryIntracranial metastasesLarge brain metastasesSingle-session radiosurgerySRSStereotactic radiosurgery

Identifiers

PMID36702970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.