ArticleNature biotechnology2023
A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Abstract read
In one paragraph
Article in Nature biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large-Fragment DNA Insertion.Plant, cell & environment · 2026Review
- Using enantioselective biosensors to evolve asymmetric biocatalysts.Nature chemical biology · 2026Article
- Incorporating AI-optimized zinc finger proteins enhances the efficiencies and targeting ranges of miniature base editors.Nature communications · 2026Article
- Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.Clinical epigenetics · 2026Review
- Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner.PLoS genetics · 2026Article
- Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells.Nature biotechnology · 2026Article
- A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications.Nature communications · 2026Article
- Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.Biomolecules · 2026Article
- Zinc finger proteins (ZFPs) in health and disease.Molecular biomedicine · 2026Review
- Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026Review
- Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects.Synthetic and systems biotechnology · 2026Review
- Allosteric and energetic remodeling of a PDZ domain by protein domain extensions.Nature communications · 2026Article
- Article
- Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Precision gene editing: The power of CRISPR-Cas in modern genetics.Molecular therapy. Nucleic acids · 2025Review
- DeepBovC2H2-ZF: deep learning-guided prediction and molecular dynamics validation of C2H2 zinc finger transcription factors in Bovidae.Journal, genetic engineering & biotechnology · 2025Article
- Animal Models of Porphyria with Hepatic Involvement.Seminars in liver disease · 2025Review
- Article
- Fifty years of monoclonals: the past, present and future of antibody therapeutics.Nature reviews. Immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
David M Ichikawa *Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7517-5150
Osama Abdin *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5471-2906
Nader AlerasoolDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Manjunatha KogenaruInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6570-7857
April L MuellerInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2134-5134
Han WenDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4680-4218
David O GigantiInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.
Gregory W GoldbergInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5022-9976
Samantha AdamsInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.
Jeffrey M SpencerInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4690-2432
Rozita RazaviDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Satra NimDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Hong ZhengDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Courtney GioncoInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.
Finnegan T ClarkInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0575-7312
Alexey StrokachDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Timothy R HughesDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-8721-4719
Timothee LionnetInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1508-0202
Mikko TaipaleDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3811-1761
Philip M KimDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. pi@kimlab.org.ORCID http://orcid.org/0000-0003-3683-152X
Marcus B NoyesInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA. marcus.noyes@nyulangone.org.ORCID http://orcid.org/0000-0002-3065-1096
Funding
The systematic definition of human protein-peptide interactions, their variants, and the microbiomeR01GM133936 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOYES, MARCUS BLAINE · 2019 to 2022
$2.1MDefining the multi-dimensional code of zinc finger specificity-Resubmission-1R01GM118851 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOYES, MARCUS BLAINE · 2017 to 2021
$2.0MNIGMS NIH HHS R01 GM118851NIGMS NIH HHS R01 GM133936
Abstract
Cys
Indexed as
Deep LearningTranscription FactorsDNAGene Expression RegulationHumansZinc FingersDNATranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.