Evidence map›Paper›PMID 36702747›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2023

A Method to Amend Cigarettes With Menthol for Use in Research.

Kia J Jackson, Megan J Schroeder, Jiu Ai, Kenneth M Taylor, Olusola Oniyide, Lauren C Viray, Carson Smith, Bartosz Koszowski, Jenny M Butler, Wallace B Pickworth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. A Method for Amending Loose Smokeless Tobacco With Menthol for Administration in Clinical Studies.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kia J JacksonFood and Drug Administration, Center for Tobacco Products, Office of Science, 11785 Beltsville Drive, Calverton, MD 20705, USA.ORCID 0000-0002-3913-8774
Megan J SchroederFood and Drug Administration, Center for Tobacco Products, Office of Science, 11785 Beltsville Drive, Calverton, MD 20705, USA.
Jiu AiFood and Drug Administration, Center for Tobacco Products, Office of Science, 11785 Beltsville Drive, Calverton, MD 20705, USA.
Kenneth M TaylorFood and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.ORCID 0000-0002-5130-5758
Olusola OniyideFood and Drug Administration, Center for Tobacco Products, Office of Science, 11785 Beltsville Drive, Calverton, MD 20705, USA.
Lauren C VirayBattelle Center for Public Health Research, 6115 Falls Road, Suite 200, Baltimore, MD 21209, USA.
Carson SmithBattelle Center for Public Health Research, 6115 Falls Road, Suite 200, Baltimore, MD 21209, USA.
Bartosz KoszowskiBattelle Center for Public Health Research, 6115 Falls Road, Suite 200, Baltimore, MD 21209, USA.
Jenny M ButlerBattelle Center for Public Health Research, 505 King Avenue, Columbus, OH 43201, USA.
Wallace B PickworthBattelle Center for Public Health Research, 6115 Falls Road, Suite 200, Baltimore, MD 21209, USA.ORCID 0000-0003-3310-2567
Battelle · USOffice of Science · USCenter for Veterinary Medicine · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

introductionStudies have evaluated the role of menthol cigarettes on various addiction-related outcomes; however, the effect of varying menthol content on these outcomes has not been evaluated. We developed a method to amend non-menthol SPECTRUM Research Cigarettes to contain menthol at four different levels. AIMS AND

methodsSPECTRUM Research Cigarettes, NRC 600 (0.8 mg nicotine; 10 mg tar), were modified to contain target menthol amounts at 3, 6, and 12 mg/cigarette by injecting 25 µL ethanol/triacetin/menthol solutions of varying concentrations (120 mg menthol/mL, 240 mg/mL, and 480 mg/mL) into four distinct locations in the filter and tobacco rod. Menthol content was tested in triplicate in the whole cigarette and in the tobacco rod and filter at 1, 24, 48, and 72 hours for each target menthol level using an extraction solution of quinoline in methyl-tert-butyl ether and measured using gas chromatography with flame ionization detection.

resultsInjections into the filter and tobacco rod (12.5 µL each) yielded equal menthol distribution up to 72 hours. However, total menthol content decreased from an average of 90.3% of the target menthol concentration at 1 hour to 80.7% at 72 hours in cigarettes stored individually in glass tubes at room temperature. Analysis of urinary menthol glucuronide confirmed that amended cigarettes used within 24 hours of injection delivered dose-related menthol levels to participants in a clinical laboratory setting.

conclusionThis method can be used to modify cigarettes with a range of reliable menthol levels in both filter and tobacco rod for use in laboratory and clinical research. IMPLICATIONS: This study presents a technique for modifying cigarettes with different levels of menthol that can reliably deliver dose-related menthol levels to participants when smoked in a clinical study. The technique can be used to quickly amend cigarettes to examine the independent effects of varying flavor and additive levels on smoking behavior, nicotine pharmacokinetics, mainstream smoke emissions, and other laboratory or clinical research outcomes.

Indexed as

NicotineTobacco ProductsHumansSmokeSmokingNicotineSmoke

Identifiers

PMID36702747
PMCPMC10202838
OpenAlexW4318264115

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.