ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2023
Underlying cancer risk among patients with fatigue and other vague symptoms: a population-based cohort study in primary care.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Fatigue Among Adults Age 18 and Older: United States, 2024.National health statistics reports · 2026Article
- Additional Investigations and Referrals by Primary Care Physicians in Uncertain Clinical Situations: Cross-Sectional Study Using Virtual Patient-Based Scenarios.JMIR formative research · 2026Article
- Evaluation of trajectory analysis for disease risk assessment: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2026Article
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- Article
- Underlying disease risk among patients with fatigue: a population-based cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy.World journal of psychiatry · 2024Article
- Cancer incidence and competing mortality risk following 15 presenting symptoms in primary care: a population-based cohort study using electronic healthcare records.BMJ oncology · 2024Article
- Breaking barriers: enhancing cancer detection in younger patients by overcoming diagnostic bias in primary care.Frontiers in medicine · 2024Article
- Self-ageism among older rural people.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
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4 authors.
Funding
Abstract
backgroundPresenting to primary care with fatigue is associated with slightly increased cancer risk, although it is unknown how this varies in the presence of other 'vague' symptoms.
aimTo quantify cancer risk in patients with fatigue who present with other 'vague' symptoms in the absence of 'alarm' symptoms for cancer. DESIGN AND
settingCohort study of patients presenting in UK primary care with new-onset fatigue during 2007-2015, using Clinical Practice Research Datalink data linked to national cancer registration data.
methodPatients presenting with fatigue without co-occurring alarm symptoms or anaemia were identified, who were further characterised as having co-occurrence of 19 other 'vague' potential cancer symptoms. Sex- and age-specific 9-month cancer risk for each fatigue-vague symptom cohort were calculated.
resultsOf 285 382 patients presenting with new-onset fatigue, 84% (
conclusionIn the absence of alarm symptoms or anaemia, fatigue combined with specific vague presenting symptoms, alongside patient age and sex, can guide clinical decisions about referral for suspected cancer.
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