Evidence map›Paper›PMID 36702514›Full record

ArticleAge and ageing2023

Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points.

Marie-Theres Huemer, Alexander Kluttig, Beate Fischer, Wolfgang Ahrens, Stefanie Castell, Nina Ebert, Sylvia Gastell, Karl-Heinz Jöckel, Rudolf Kaaks, André Karch and 20 more

Abstract read
In one paragraph

Article in Age and ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Hand grip strength and loss of independence in Indigenous and non-Indigenous New Zealand octogenarians-the LiLACS NZ cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Marie-Theres HuemerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Alexander KluttigInstitute of Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Beate FischerDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Wolfgang AhrensLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Stefanie CastellDepartment for Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Nina EbertInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany.
Sylvia GastellNAKO Study Center South Berlin/Brandenburg, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Karl-Heinz JöckelInstitut für Medizinische Informatik, Biometrie und Epidemiologie, Universitätsklinikum Essen, Essen, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Yvonne KemmlingDepartment for Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Michael LeitzmannDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Claudia Meinke-FranzeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Karin B MichelsInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Rafael MikolajczykInstitute of Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-3125-7859
Ilais Moreno VelásquezMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Tobias PischonMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Sabine SchipfInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Börge SchmidtInstitut für Medizinische Informatik, Biometrie und Epidemiologie, Universitätsklinikum Essen, Essen, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Hannah StockerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Henning TeismannInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Kerstin WirknerLIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Michael DreyDepartment of Medicine IV, University Hospital, LMU Munich, Geriatrics, 80336 Munich, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Barbara ThorandInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0002-5667-6849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies.

objectiveComparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample.

methodsWe assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality.

resultsGrip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality.

conclusionsCut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.

Indexed as

SarcopeniaAgedFemaleGeriatric AssessmentHand StrengthHumansMalePrevalencecut-off pointsEuropean Working Group on Sarcopenia in Older People (EWGSOP)grip strengthmortalityprobable sarcopenia

Identifiers

PMID36702514
PMCPMC9879709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.