Evidence map›Paper›PMID 36702499›Full record

ArticleAJNR. American journal of neuroradiology2023

Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy.

E H Middlebrooks, R A Popple, E Greco, L Okromelidze, H C Walker, D A Lakhani, A R Anderson, E M Thomas, H D Deshpande, B A McCullough and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

E H MiddlebrooksFrom the Departments of Radiology (E.H.M., E.G., L.O., D.A.L.) Middlebrooks.Erik@mayo.edu.ORCID 0000-0002-4418-9605
R A PoppleDepartments of Radiation Oncology (R.A.P., A.R.A., E.M.T., M.B.).ORCID 0000-0003-1252-738X
E GrecoFrom the Departments of Radiology (E.H.M., E.G., L.O., D.A.L.).ORCID 0000-0002-2738-8143
L OkromelidzeFrom the Departments of Radiology (E.H.M., E.G., L.O., D.A.L.).ORCID 0000-0002-1296-0522
H C WalkerNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0002-4601-3486
D A LakhaniFrom the Departments of Radiology (E.H.M., E.G., L.O., D.A.L.).ORCID 0000-0001-7577-1887
A R AndersonDepartments of Radiation Oncology (R.A.P., A.R.A., E.M.T., M.B.).ORCID 0000-0003-3576-9648
E M ThomasDepartments of Radiation Oncology (R.A.P., A.R.A., E.M.T., M.B.).
H D DeshpandeRadiology (H.D.D.).ORCID 0000-0001-7077-240X
B A McCulloughNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).
N P StoverNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0001-9684-1813
V W SungNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0003-1024-3404
A P NicholasNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).
D G StandaertNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0003-2921-8348
T YacoubianNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0003-2227-7310
M N DeanNeurology (H.C.W., B.A.M., N.P.S., V.W.S., A.P.N., D.G.S., T.Y., M.N.D.).ORCID 0000-0002-9318-769X
J A RoperSchool of Kinesiology (J.A.R.), Auburn University, Auburn, Alabama.ORCID 0000-0002-2047-8760
S S GrewalNeurosurgery (E.H.M., S.S.G.), Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-4307-7062
M T HollandNeurosurgery (M.T.H., J.N.B., B.L.G.), University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-4936-4193
J N BentleyNeurosurgery (M.T.H., J.N.B., B.L.G.), University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-8303-071X
B L GuthrieNeurosurgery (M.T.H., J.N.B., B.L.G.), University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-0428-3047
M BredelDepartments of Radiation Oncology (R.A.P., A.R.A., E.M.T., M.B.).ORCID 0000-0002-7828-0984
Norwegian Womens Public Health Association · NOMACOM (United States) · USUniversity of Alabama at Birmingham · USAuburn University · USHarley-Davidson (United States) · USJacksonville College · USMayo Clinic · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeGiven the increased use of stereotactic radiosurgical thalamotomy and other ablative therapies for tremor, new biomarkers are needed to improve outcomes. Using resting-state fMRI and MR tractography, we hypothesized that a "connectome fingerprint" can predict tremor outcomes and potentially serve as a targeting biomarker for stereotactic radiosurgical thalamotomy. MATERIALS AND

methodsWe evaluated 27 patients who underwent unilateral stereotactic radiosurgical thalamotomy for essential tremor or tremor-predominant Parkinson disease. Percentage postoperative improvement in the contralateral limb Fahn-Tolosa-Marin Clinical Tremor Rating Scale (TRS) was the primary end point. Connectome-style resting-state fMRI and MR tractography were performed before stereotactic radiosurgery. Using the final lesion volume as a seed, "connectivity fingerprints" representing ideal connectivity maps were generated as whole-brain R-maps using a voxelwise nonparametric Spearman correlation. A leave-one-out cross-validation was performed using the generated R-maps.

resultsThe mean improvement in the contralateral tremor score was 55.1% (SD, 38.9%) at a mean follow-up of 10.0 (SD, 5.0) months. Structural connectivity correlated with contralateral TRS improvement (

conclusionsStereotactic radiosurgical targets with a distinct connectivity profile predict improvement in tremor after treatment. Such connectomic fingerprints show promise for developing patient-specific biomarkers to guide therapy with stereotactic radiosurgical thalamotomy.

Indexed as

ConnectomeEssential TremorRadiosurgeryHumansMagnetic Resonance ImagingThalamusTreatment OutcomeTremor

Identifiers

PMID36702499
PMCPMC9891328
OpenAlexW4318071516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.