Evidence map›Paper›PMID 36702343›Full record

SynthesisFertility and sterility2023

Effect of female coronavirus disease 2019 vaccination on assisted reproductive outcomes: a systematic review and meta-analysis.

Jialyu Huang, Zheng Fang, Yiqi Liu, Chutian Xing, Lingling Huang, Jiaqin Mao, Houyang Chen, Zhihui Huang, Leizhen Xia, Liang Tang and 6 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Fertility and sterility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jialyu HuangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Zheng FangCenter for Reproductive Medicine, Department of Gynecology and Obstetrics, Tangdu Hospital, Air Force Medical University, Xi'an, People's Republic of China.
Yiqi LiuDepartment of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, People's Republic of China.
Chutian XingDepartment of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, People's Republic of China.
Lingling HuangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Jiaqin MaoCenter for Reproductive Medicine, Department of Gynecology and Obstetrics, Tangdu Hospital, Air Force Medical University, Xi'an, People's Republic of China.
Houyang ChenCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Zhihui HuangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Leizhen XiaCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Liang TangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Zhiqin ZhangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Bingqin LiuDepartment of Obstetrics, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Hua HuangCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Lifeng TianCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Xiaoyan AiDepartment of Gynecology, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China.
Qiongfang WuCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of the National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, People's Republic of China. Electronic address: wuqfivf@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceThe effect of coronavirus disease 2019 (COVID-19) vaccination on fertility warrants clarification in women undergoing assisted reproductive treatment.

objectiveTo study the association between female COVID-19 vaccination and outcomes of assisted reproductive treatment. DATA SOURCES: PubMed, Embase, the Web of Science, Cochrane Library, and medRxiv and bioRxiv were searched for eligible studies from December 1, 2019, to November 30, 2022, with no language restrictions. STUDY SELECTION AND SYNTHESIS: Observational studies comparing assisted reproductive outcomes between women with and without COVID-19 vaccination were included. The pooled estimates were calculated using the random-effects models as mean differences (MDs), standardized MDs, or odds ratios with 95% confidence intervals (CIs). Heterogeneity was evaluated using the I MAIN OUTCOMES: The number of oocytes retrieved and clinical pregnancy rate.

resultsTwenty-one cohort studies involving a total of 19,687 treatment cycles were included. In a comparison of the vaccinated vs. unvaccinated groups, the pooled MD for oocyte number was -0.06 (95% CI, -0.51 to 0.39; I CONCLUSION AND RELEVANCE: Our work did not find significant differences in assisted reproductive outcomes between vaccinated and unvaccinated women. However, more data are warranted to confirm the safety of COVID-19 vaccination for assisted reproductive treatment and in female fertility in general.

Indexed as

Abortion, SpontaneousCOVID-19COVID-19 VaccinesFemaleHumansLive BirthPregnancyPregnancy RateCOVID-19 Vaccinesassisted reproductive technologyCOVID-19fertilitySARS-CoV-2vaccine

Identifiers

PMID36702343
PMCPMC9868006

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.