Evidence map›Paper›PMID 36702211›Full record

ReviewNeuroImage2023

Applications of generative adversarial networks in neuroimaging and clinical neuroscience.

Rongguang Wang, Vishnu Bashyam, Zhijian Yang, Fanyang Yu, Vasiliki Tassopoulou, Sai Spandana Chintapalli, Ioanna Skampardoni, Lasya P Sreepada, Dushyant Sahoo, Konstantina Nikita and 3 more

Abstract readReview
In one paragraph

Review in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rongguang WangCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA. Electronic address: rgw@seas.upenn.edu.
Vishnu BashyamCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Zhijian YangCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Fanyang YuCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Vasiliki TassopoulouCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Sai Spandana ChintapalliCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Ioanna SkampardoniCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA; School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
Lasya P SreepadaCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Dushyant SahooCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Konstantina NikitaSchool of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
Ahmed AbdulkadirCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA; Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Junhao WenCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA.
Christos DavatzikosCenter for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address: christos.davatzikos@pennmedicine.upenn.edu.

Funding

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Statistical atlases of brain tumor MRI:do imaging phenotypes predict progression?R01NS042645 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2002 to 2024
$8.7M
Machine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortiumRF1AG054409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2023
$6.3M
Generalizable quantitative imaging and machine learning signatures in glioblastoma, for precision diagnostics and personalized treatment: the ReSPOND consortiumR01CA269948 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Christos Davatzikos · 2022 to 2026
$3.2M
Mapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern AnalysisR01MH112070 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2020
$2.7M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NCI NIH HHS R01 CA269948NIA NIH HHS RF1 AG054409NIA NIH HHS U01 AG068057NIDA NIH HHS 75N95019C00022NIDA NIH HHS HHSN271201300284PNIH HHS S10 OD023495NIMH NIH HHS R01 MH112070NINDS NIH HHS R01 NS042645
6 · The paper itself

Abstract

Generative adversarial networks (GANs) are one powerful type of deep learning models that have been successfully utilized in numerous fields. They belong to the broader family of generative methods, which learn to generate realistic data with a probabilistic model by learning distributions from real samples. In the clinical context, GANs have shown enhanced capabilities in capturing spatially complex, nonlinear, and potentially subtle disease effects compared to traditional generative methods. This review critically appraises the existing literature on the applications of GANs in imaging studies of various neurological conditions, including Alzheimer's disease, brain tumors, brain aging, and multiple sclerosis. We provide an intuitive explanation of various GAN methods for each application and further discuss the main challenges, open questions, and promising future directions of leveraging GANs in neuroimaging. We aim to bridge the gap between advanced deep learning methods and neurology research by highlighting how GANs can be leveraged to support clinical decision making and contribute to a better understanding of the structural and functional patterns of brain diseases.

Indexed as

Alzheimer DiseaseNeurosciencesAgingBrainHumansNeuroimagingGANGenerative adversarial networkNeuroimagingPathologyReview

Identifiers

PMID36702211
PMCPMC9992336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.