Evidence map›Paper›PMID 36702023›Full record

ArticleWater research2023

Wastewater surveillance of SARS-CoV-2 and influenza in preK-12 schools shows school, community, and citywide infections.

Madeline Wolken, Thomas Sun, Camille McCall, Rebecca Schneider, Kelsey Caton, Courtney Hundley, Loren Hopkins, Katherine Ensor, Kaavya Domakonda, Prashant Kalvapalle and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Water research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Madeline WolkenDepartment of Civil and Environmental Engineering, Rice University, 6100 Main Street MS-519, Houston, TX, USA; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center, 1200 Pressler Street, Houston, TX, USA.
Thomas SunDepartment of Statistics, Rice University, 6100 Main Street MS 138, Houston, TX, USA.
Camille McCallDepartment of Civil and Environmental Engineering, Rice University, 6100 Main Street MS-519, Houston, TX, USA.
Rebecca SchneiderHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Kelsey CatonHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Courtney HundleyHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Loren HopkinsDepartment of Statistics, Rice University, 6100 Main Street MS 138, Houston, TX, USA; Houston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Katherine EnsorDepartment of Statistics, Rice University, 6100 Main Street MS 138, Houston, TX, USA.
Kaavya DomakondaHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Prashant KalvapalleSystems, Synthetic, and Physical Biology, Rice University, Houston, TX, USA.
David PersseHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA; Department of Medicine and Surgery, Baylor College of Medicine, Houston, TX, USA; City of Houston Emergency Medical Services, Houston, TX, USA.
Stephen WilliamsHouston Health Department, 8000 N. Stadium Dr., Houston, TX, USA.
Lauren B StadlerDepartment of Civil and Environmental Engineering, Rice University, 6100 Main Street MS-519, Houston, TX, USA. Electronic address: lauren.stadler@rice.edu.
Houston Health and Human Services Department · USRice University · USTexas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wastewater surveillance is a passive and efficient way to monitor the spread of infectious diseases in large populations and high transmission areas such as preK-12 schools. Infections caused by respiratory viruses in school-aged children are likely underreported, particularly because many children may be asymptomatic or mildly symptomatic. Wastewater monitoring of SARS-CoV-2 has been studied extensively and primarily by sampling at centralized wastewater treatment plants, and there are limited studies on SARS-CoV-2 in preK-12 school wastewater. Similarly, wastewater detections of influenza have only been reported in wastewater treatment plant and university manhole samples. Here, we present the results of a 17-month wastewater monitoring program for SARS-CoV-2 (n = 2176 samples) and influenza A and B (n = 1217 samples) in 51 preK-12 schools. We show that school wastewater concentrations of SARS-CoV-2 RNA were strongly associated with COVID-19 cases in schools and community positivity rates, and that influenza detections in school wastewater were significantly associated with citywide influenza diagnosis rates. Results were communicated back to schools and local communities to enable mitigation strategies to stop the spread, and direct resources such as testing and vaccination clinics. This study demonstrates that school wastewater surveillance is reflective of local infections at several population levels and plays a crucial role in the detection and mitigation of outbreaks.

Indexed as

COVID-19Influenza, HumanChildHumansRNA, ViralSARS-CoV-2WastewaterWastewater-Based Epidemiological MonitoringRNA, ViralWastewaterCOVID-19InfluenzapreK-12 schoolsSARS-CoV-2Wastewater-based epidemiology

Identifiers

PMID36702023
PMCPMC9858235
OpenAlexW4318263908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.