Evidence map›Paper›PMID 36701865›Full record

ArticleJournal of colloid and interface science2023

Cancer cells inhibition by cationic carbon dots targeting the cellular nucleus.

Jiuyan Chen, Fang Li, Jun Gu, Xiao Zhang, Mattia Bartoli, Justin B Domena, Yiqun Zhou, Wei Zhang, Victor Paulino, Braulio C L B Ferreira and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Antibacterial carbon dots.Materials today. Bio · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jiuyan ChenDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Fang LiDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, FL 33136, USA.
Jun GuDepartment of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, FL 33136, USA.
Xiao ZhangDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Mattia BartoliDepartment of Applied Science and Technology, Politecnico di Torino, Italy.
Justin B DomenaDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Yiqun ZhouDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA; C-Dots, LLC, Miami, FL 33136, USA.
Wei ZhangDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Victor PaulinoDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Braulio C L B FerreiraDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Nicholas Michael BrejchaDepartment of Biochemistry and Molecular Biology, University of Miami, Coral Gables, FL 33146, USA.
Liang LuoDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, FL 33136, USA.
Chiara ArduinoDepartment of Applied Science and Technology, Politecnico di Torino, Italy.
Fulvia VerdeDepartment of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, FL 33136, USA.
Fangliang ZhangDepartment of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, FL 33136, USA.
Fuwu ZhangDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Alberto TagliaferroDepartment of Applied Science and Technology, Politecnico di Torino, Italy.
Jean-Hubert OlivierDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Yanbin ZhangDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, FL 33136, USA. Electronic address: yzhang4@med.miami.edu.
Roger M LeblancDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA. Electronic address: rml@miami.edu.

Funding

Defining role of FANCA in genome instabilityR01HL156958 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHANG, YANBIN · 2021 to 2023
$1.4M
Targeted degradation of proteins by affinity peptide conjugated ubiquitin (APCU)R21CA250597 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHANG, FANGLIANG · 2021 to 2023
$528k
NCI NIH HHS R21 CA250597NHLBI NIH HHS R01 HL156958
6 · The paper itself

Abstract

Nucleus targeting is tremendously important in cancer therapy. Cationic carbon dots (CCDs) are potential nanoparticles which might enter cells and penetrate nuclear membranes. Although some CCDs have been investigated in nucleus targeting and applied in nuclear imaging, the CCDs derived from drugs, that are able to target the nucleus, bind with DNA and inhibit the growth of cancer cells have not been reported. In this project, 1, 2, 4, 5-benzenetetramine (Y15, a focal adhesion kinase inhibitor) derived cationic carbon dots (Y15-CDs) were prepared via a hydrothermal approach utilizing Y15, folic acid and 1,2-ethylenediamine as precursors. Based on the structural, optical, and morphologic characterizations, Y15-CDs possess rich amine groups and nitrogen in structure, an excitation-dependent photoluminescence emission, and a small particle size of 2 to 4 nm. The DNA binding experiments conducted through agarose gel electrophoresis, UV-vis absorption, fluorescence emission, and circular dichroism spectroscopies, prove that Y15-CDs might bind with DNA via electrostatic interactions and partially intercalative binding modes. In addition, the cell imaging and cytotoxicity studies in human foreskin fibroblasts (HFF), prostate cancer (PC3) and osteosarcoma cells (U2OS) indicate the nucleus targeting and anticancer abilities of Y15-CDs. Most interestingly, Y15-CDs exhibit a higher cytotoxicity to cancer cells (PC3 and U2OS) than to normal cells (HFF), inferring that Y15-CDs might be potentially applied in cancer therapy.

Indexed as

NanoparticlesNeoplasmsQuantum DotsCarbonDNAFluorescent DyesHumansMaleSpectrometry, FluorescenceCarbonDNAFluorescent Dyes1,2,4,5-benzenetetramineCancer therapyCationic carbon dotsDNA bindingNucleus targeting

Identifiers

PMID36701865
PMCPMC9957951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.