ReviewDiabetes care2023
Brain Glucose Sensing and the Problem of Relative Hypoglycemia.
Review in Diabetes care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The association between the stress hyperglycaemia ratio and mortality in cardiovascular disease: a meta-analysis and systematic review.Cardiovascular diabetology · 2024Pooled it
- Habituation to Elevated Glucose Levels in Type 1 Diabetes: Function and Well-being in Guideline-Based Versus Typical Glycemic Range.Diabetes care · 2026Article
- Blood glucose trajectory phenotypes are associated with in-hospital mortality in a multicenter ICU stroke cohort.Scientific reports · 2026Article
- Atypical Hypoglycemia-Induced Stroke Mimic: A Case Report and Literature Review.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management.Frontiers in endocrinology · 2026Review
- Artificial pancreas: the past and the future.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Linking glucose swings and mental health to cardiovascular outcomes and mortality in general practice.Scientific reports · 2025Article
- Predictive Model for Hypoglycaemia Risk in Type 2 Diabetes Mellitus Patients During the Peri-Colonoscopy Period: A Retrospective Cohort Study.Journal of advanced nursing · 2025Article
- Accelerated biological aging mediates the associations of stress hyperglycemia ratio (SHR) with mortality in type 2 diabetes and obesity (diabesity).Cardiovascular diabetology · 2025Article
- Cardiac arrhythmia and hypoglycaemia among individuals with and without diabetes receiving haemodialysis (the CADDY study): a Danish multicentre cohort study.Diabetologia · 2025Observational
- Sea Urchin-like Magnetic Microbeads-Based Electrochemical Biosensor for Highly Sensitive Detection of Metabolites.Biosensors · 2025Article
- Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Exploring the correlation between corrective glucose treatment and long-term patient outcomes: a SHINE secondary analysis.Frontiers in neurology · 2025Article
- The stress hyperglycemia ratio as a predictor of short- and long-term mortality in patients with acute brain injury: a retrospective cohort study.Frontiers in neurology · 2025Article
- Brain Defense of Glycemia in Health and Diabetes.Diabetes · 2024Review
- Orexin neurons track temporal features of blood glucose in behaving mice.Nature neuroscience · 2024Article
- [Life-threatening euglycemic ketoacidosis under treatment with empagliflozin in cardiac surgery patients: rare isolated case or a frequent problem in the future?]Die Anaesthesiologie · 2024Article
- Glycemic control and clinical outcomes in diabetic patients with heart failure and reduced ejection fraction: insight from ventricular remodeling using cardiac MRI.Cardiovascular diabetology · 2024Article
- Differential Association between Blood Glucose Levels and Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation Based on Presence or Absence of Preexisting Diabetes.Transplantation and cellular therapy · 2024Article
- Dynamic associations between glucose and ecological momentary cognition in Type 1 Diabetes.NPJ digital medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
"Relative hypoglycemia" is an often-overlooked complication of diabetes characterized by an increase in the glycemic threshold for detecting and responding to hypoglycemia. The clinical relevance of this problem is linked to growing evidence that among patients with critical illness, higher blood glucose in the intensive care unit is associated with higher mortality among patients without diabetes but lower mortality in patients with preexisting diabetes and an elevated prehospitalization HbA1c. Although additional studies are needed, the cardiovascular stress associated with hypoglycemia perception, which can occur at normal or even elevated glucose levels in patients with diabetes, offers a plausible explanation for this difference in outcomes. Little is known, however, regarding how hypoglycemia is normally detected by the brain, much less how relative hypoglycemia develops in patients with diabetes. In this article, we explore the role in hypoglycemia detection played by glucose-responsive sensory neurons supplying peripheral vascular beds and/or circumventricular organs. These observations support a model wherein relative hypoglycemia results from diabetes-associated impairment of this neuronal glucose-sensing process. By raising the glycemic threshold for hypoglycemia perception, this impairment may contribute to the increased mortality risk associated with standard glycemic management of critically ill patients with diabetes.
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