Evidence map›Paper›PMID 36701240›Full record

ArticleDevelopmental medicine and child neurology2023

Determinants of gait dystonia severity in cerebral palsy.

Bhooma R Aravamuthan, Toni S Pearson, Keisuke Ueda, Hanyang Miao, Gazelle Zerafati-Jahromi, Laura Gilbert, Cynthia Comella, Joel S Perlmutter

Open access · bronzeAbstract read
In one paragraph

Article in Developmental medicine and child neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
  2. Characteristics of Cerebral Palsy in the Midwestern US.Annals of clinical and translational neurology · 2026
    Article
  3. Video-Based Data-Driven Models for Diagnosing Movement Disorders: Review and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  4. Tasks for assessing dystonia in young people with cerebral palsy.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Using expert-cited features to detect leg dystonia in cerebral palsy.medRxiv : the preprint server for health sciences · 2025
    Article
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  11. Caregiver descriptions of dystonia in cerebral palsy.Annals of clinical and translational neurology · 2024
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bhooma R AravamuthanDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-0205-2149
Toni S PearsonDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Keisuke UedaDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-4087-6018
Hanyang MiaoDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Gazelle Zerafati-JahromiDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Laura GilbertDivision of Pediatric Neurology, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Cynthia ComellaDepartment of Neurological Sciences, Rush University, Chicago, IL, USA.
Joel S PerlmutterDepartments of Neurology, Radiology, Neuroscience, Physical Therapy, and Occupational Therapy, Washington University School of Medicine, St Louis, MO, USA.
Washington University in St. Louis · USRush University · US

Funding

A Safety and Efficacy Study of AAV2-hAADC for AADC DeficiencyR01NS094292 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Krystof S Bankiewicz · 2016 to 2026
$17.3M
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsyK08NS117850 · NINDS · WASHINGTON UNIVERSITY · PI ARAVAMUTHAN, BHOOMA · 2021 to 2025
$927k
NINDS NIH HHS K08 NS117850NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS094292NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS124789NINDS NIH HHS RF1 NS075321NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

aimTo determine the movement features governing expert assessment of gait dystonia severity in individuals with cerebral palsy (CP).

methodIn this prospective cohort study, three movement disorder neurologists graded lower extremity dystonia severity in gait videos of individuals with CP using a 10-point Likert-like scale. Using conventional content analysis, we determined the features experts cited when grading dystonia severity. Then, using open-source pose estimation techniques, we determined gait variable analogs of these expert-cited features correlating with their assessments of dystonia severity.

resultsExperts assessed videos from 116 participants (46 with dystonia aged 15 years [SD 3] and 70 without dystonia aged 15 years [SD 2], both groups ranging 10-20 years old and 50% male). Variable limb adduction was most commonly cited by experts when identifying dystonia, comprising 60% of expert statements. Effect on gait (regularity, stability, trajectory, speed) and dystonia amplitude were common features experts used to determine dystonia severity, comprising 19% and 13% of statements respectively. Gait variables assessing adduction variability and amplitude (inter-ankle distance variance and foot adduction amplitude) were significantly correlated with expert assessment of dystonia severity (multiple linear regression, p < 0.001).

interpretationAdduction variability and amplitude are quantifiable gait features that correlate with expert-determined gait dystonia severity in individuals with CP. Consideration of these features could help optimize and standardize the clinical assessment of gait dystonia severity in individuals with CP.

Indexed as

Cerebral PalsyDystoniaDystonic DisordersMovement DisordersAdolescentAdultBiomechanical PhenomenaChildFemaleGaitHumansMaleProspective StudiesYoung Adult

Identifiers

PMID36701240
PMCPMC10392706
OpenAlexW4318165592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.