ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023
Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 · What the graph read from it
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2 · The registry
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3 · Its place in the literature
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1 citing paper in PubMed, 0 citations in OpenAlex.
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5 · Who and what money
Authors and funding
12 authors at 1 institution in 1 country.
Lais Cavalcanti Dos Santos Velasco de Souza *Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.ORCID http://orcid.org/0000-0003-0245-2687
Nathália Faria Reis *Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.ORCID http://orcid.org/0000-0001-8436-292X
Lucas Martins AlcântaraCenter for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.ORCID http://orcid.org/0000-0001-6068-0034
Simone Rocha Leal da Silveira SoutoCenter for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.ORCID http://orcid.org/0000-0001-8755-1128
Bruno de Araújo PennaLaboratory of Gram Positive Cocos, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-7880-9270
Renan Caetano Souza SantosNatural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Francisco Paiva MachadoNatural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-5332-9972
Helena Carla CastroLaboratory of Antibiotics, Biochemistry and Molecular Modeling, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-5283-1541
Ricardo Luiz Dantas MachadoCenter for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.ORCID http://orcid.org/0000-0002-8955-3204
Leandro RochaNatural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-0484-1918
Andréa Regina de Souza BaptistaCenter for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil. andrearegina@id.uff.br.ORCID http://orcid.org/0000-0002-0461-7521
Universidade Federal Fluminense · BR
Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico PIBIC-CNPq/UFFConselho Nacional de Desenvolvimento Científico e Tecnológico PQ-CNPqCoordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.001882/2014
6 · The paper itself
Abstract
Sporothrix brasiliensis with low susceptibility isolates were described from the Brazilian zoonotic sporotrichosis hyperendemics. The aim of this work was to evaluate distinct fractions of Ocotea pulchella, Ocotea notata, Myrciaria floribunda, and Hypericum brasiliense plant extracts against itraconazole-sensitive and low susceptibility S. brasiliensis isolates. Crude extracts were tested against clinical isolates and the ATCC MYA4823 to determine the minimum inhibitory concentrations (MICs) and fungicidal or fungistatic activities (MFC). A high MICs and MFCs amplitude (1 - > 128 µg/mL) were obtained for seven extracts. The highest antimicrobial activities against sensitive S. brasiliensis were displayed by the ethyl acetate extracts of O. notata (MIC = 2-128 μg/mL) and M. floribunda (MIC = 1-8 μg/mL). A fungicidal effect was observed for all fraction extracts. Ocotea spp. and M. floribunda ethyl acetate extracts provide promising profiles against itraconazole-sensitive or low susceptibility S. brasiliensis. Future studies will determine if these extracts can contribute as alternative therapies to this neglected zoonosis.
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Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole. · full record | OpenQuestion