Evidence map›Paper›PMID 36701038›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Effectiveness of a vitamin D regimen in deficient multiple myeloma patients and its effect on peripheral neuropathy.

Berdien E Oortgiesen, Marloes Dekens, Ruud Stapel, Abdulrazzaq Alheraky, Pauline de Keizer Dannenberg, Claire Siemes, Frank G A Jansman, Robby E Kibbelaar, Nic J G M Veeger, Mels Hoogendoorn and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Assessment tools for peripheral neuropathy in multiple myeloma.The Korean journal of internal medicine · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. The impact of vitamin D on cancer: A mini review.The Journal of steroid biochemistry and molecular biology · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Berdien E OortgiesenDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, the Netherlands.
Marloes DekensDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, the Netherlands.
Ruud StapelDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, the Netherlands.
Abdulrazzaq AlherakyDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, the Netherlands.
Pauline de Keizer DannenbergDepartment of Hematology, Deventer Hospital, Deventer, the Netherlands.
Claire SiemesDepartment of Hematology, Deventer Hospital, Deventer, the Netherlands.
Frank G A JansmanUnit of Pharmacotherapy, Epidemiology and Economics, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.
Robby E KibbelaarDepartment of Pathology, Pathology Friesland, Leeuwarden, the Netherlands.
Nic J G M VeegerDepartment of Epidemiology, MCL Academy, Leeuwarden, the Netherlands.
Mels HoogendoornDepartment of Hematology, Medical Centre Leeuwarden, Leeuwarden, the Netherlands.
Eric N van RoonDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, P.O. Box 888, 8901 BR, Leeuwarden, the Netherlands. E.N.van.Roon@mcl.nl.
Medisch Centrum Leeuwarden · NLDeventer Ziekenhuis · NLFriesland College · NLUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeripheral neuropathy (PN) is common in multiple myeloma (MM) patients. More insight has been gained concerning the role of vitamin D in preventing PN. However, studies evaluating the effects of vitamin D

methodsThirty-nine MM patients with inadequate (< 75 nmol/L [= 30 ng/mL]) 25-hydroxyvitamin D (25(OH)D) levels were included in this multicenter, prospective, single-arm study, of whom 35 patients completed the study. They received oral vitamin D

resultsMedian 25(OH)D increased from 38 (IQR 32-52) nmol/L at baseline to 77 (IQR 72-87) nmol/L after 6 months (P < 0.001). Adequate 25(OH)D levels were achieved by 66% of the subjects, and 34% were within the range of 50-75 nmol/L. Furthermore, in 37% of the participants, PN severity decreased (P = 0.007).

conclusionThe use of substantially higher vitamin D

Indexed as

Multiple MyelomaPeripheral Nervous System DiseasesVitamin D DeficiencyCholecalciferolDietary SupplementsHumansProspective StudiesVitamin DVitaminsCholecalciferolVitamin DVitamins25-Hydroxyvitamin DDose–response relationship, drugMultiple myelomaPeripheral nervous system diseasesVitamin D deficiency

Identifiers

PMID36701038
PMCPMC9879810
OpenAlexW4318055217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.