ArticleMicrobiology spectrum2023
Emergence of Antifungal Resistant Subclades in the Global Predominant Phylogenetic Population of Candida albicans.
Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Population genomics reveals a long-term increase in azole resistance associated with the emerging cluster AZR amongEmerging microbes & infections · 2026Article
- Global surveillance ofAntimicrobial agents and chemotherapy · 2026Article
- In Vitro Exposure to Vaped Tetrahydrocannabinol IncreasesMicroorganisms · 2025Article
- FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance.Nature microbiology · 2025Article
- Broad-spectrum antifungal activity of C12/C14 alkyl triphenylphosphonium salts (TPP-CFrontiers in microbiology · 2025Article
- Insights into the origin, hybridisation and adaptation of Candida metapsilosis hybrid pathogens.PLoS pathogens · 2025Article
- Article
- Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost.Nature microbiology · 2024Article
- Draft Genome Sequence of Candida saopaulonensis from a Very Premature Infant with Sepsis.Mycopathologia · 2024Article
- Anticandidal effect of multiple sessions of erythrosine and potassium iodide-mediated photodynamic therapy.Journal of oral microbiology · 2024Article
- Tandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population.Nature communications · 2023Article
- Antimicrobial effects of XF drugs againstFrontiers in fungal biology · 2023Article
Corrections and comments
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Authors and funding
29 authors.
Funding
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Abstract
Candida albicans remains the most common species causing invasive candidiasis. In this study, we present the population structure of 551 global C. albicans strains. Of these, the antifungal susceptibilities of 370 strains were tested. Specifically, 66.6% of the azole-nonsusceptible (NS)/non-wild-type (NWT) strains that were tested belonged to Clade 1. A phylogenetic analysis, a principal components analysis, the population structure, and a loss of heterozygosity events revealed two nested subclades in Clade 1, namely, Clade 1-R and Clade 1-R-α, that exhibited higher azole-NS/NWT rates (75.0% and 100%, respectively). In contrast, 6.4% (21/326) of the non-Clade 1-R isolates were NS/NWT to at least 1 of 4 azoles. Notably, all of the Clade 1-R-α isolates were pan-azole-NS/NWT that carried unique A114S and Y257H double substitutions in Erg11p and had the overexpression of ABC-type efflux pumps introduced by the substitution A736V in transcript factor Tac1p. It is worth noting that the Clade 1-R and Clade 1-R-α isolates were from different cities that are distributed over a large geographic span. Our study demonstrated the presence of specific phylogenetic subclades that are associated with antifungal resistance among C. albicans Clade 1, which calls for public attention on the monitoring of the future spread of these clones.
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