ArticleACS applied bio materials2023
4D Printing of Body Temperature-Responsive Hydrogels Based on Poly(acrylic acid) with Shape-Memory and Self-Healing Abilities.
Article in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026Review
- Next-generation epidermal patches: Bridging 3D and multidimensional printing for biomedical and personal care innovations.Bioactive materials · 2026Review
- Exploring the role of 4D printing materials, techniques, and characteristics for personalized oncology.Translational oncology · 2026Review
- Functional Materials for Additive Manufacturing: Materials Design, Processing, and Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Design and Application of Stimuli-Responsive Hydrogels for 4D Printing: A Review of Adaptive Materials in Engineering.Gels (Basel, Switzerland) · 2026Review
- 4D Printing in Regenerative Medicine: Bio-Inspired Applications for Dynamic Tissue Repair.Journal of functional biomaterials · 2026Review
- Advancing transdermal drug delivery through 4D bioprinting and dynamic skin modelling.Frontiers in drug delivery · 2026Review
- RAFT-Mediated 3D Printing of Polylactones/Itaconate Elastomers with Polypeptide Surface Functionalization.ACS polymers Au · 2025Article
- Hexadecylamine Addition Promotes Crystallization-Driven Functionalities in Freezing-Thaw PVA Hydrogels.Macromolecules · 2025Article
- Review
- A review of synergistic strategies in cancer therapy: resveratrol-loaded hydrogels for targeted and multimodal treatment.Discover oncology · 2025Review
- Stiff and self-healing hydrogels by polymer entanglements in co-planar nanoconfinement.Nature materials · 2025Article
- An insightful overview on osteogenic potential of nano hydroxyapatite for bone regeneration.Cell and tissue banking · 2025Review
- Toward Customizable Smart Gels: A Comprehensive Review of Innovative Printing Techniques and Applications.Gels (Basel, Switzerland) · 2025Review
- Review
- Advancements in Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering.Polymers · 2024Review
- Review
- Light-Assisted 3D-Printed Hydrogels for Antibacterial Applications.Small science · 2024Article
- Research Progress of Self-Healing Polymer for Ultraviolet-Curing Three-Dimensional Printing.Polymers · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additive manufacturing of smart materials that can be dynamically programmed with external stimuli is known as 4D printing. Among the 4D printable materials, hydrogels are the most extensively studied materials in various biomedical areas because of their hierarchical structure, similarity to native human tissues, and supreme bioactivity. However, conventional smart hydrogels suffer from poor mechanical properties, slow actuation speed, and instability of actuated shape. Herein, we present 4D-printed hydrogels based on poly(acrylic acid) that can concurrently possess shape-memory and self-healing properties. The printing of the hydrogels is achieved by solvent-free copolymerization of the hydrophilic acrylic acid (AAc) and hydrophobic hexadecyl acrylate (C16A) monomers in the presence of TPO photoinitiator using a stereolithography-based commercial resin printer followed by swelling in water. The printed hydrogels undergo a reversible strong-to-weak gel transition below and above human body temperature due to the melting and crystallization of the hydrophobic C16A domains. In this way, the shape-memory and self-healing properties of the hydrogels can be magically actuated near the body temperature by adjusting the molar ratio of the monomers. Furthermore, the printed hydrogels display a high Young's modulus (up to ∼215 MPa) and high toughness (up to ∼7 MJ/m
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.