Evidence map›Paper›PMID 36700404›Full record

ArticleHaematologica2023

Combination therapy of a PSEN1-selective γ-secretase inhibitor with dexamethasone and an XPO1 inhibitor to target T-cell acute lymphoblastic leukemia.

Charlien Vandersmissen, Cristina Prieto, Olga Gielen, Kris Jacobs, David Nittner, Johan Maertens, Heidi Segers, Jan Cools

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Charlien VandersmissenCenter for Human Genetics, KU Leuven, Leuven, Belgium; Center for Cancer biology, VIB, Leuven, Belgium; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven.
Cristina PrietoCenter for Human Genetics, KU Leuven, Leuven, Belgium; Center for Cancer biology, VIB, Leuven, Belgium; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven.
Olga GielenCenter for Human Genetics, KU Leuven, Leuven, Belgium; Center for Cancer biology, VIB, Leuven, Belgium; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven.
Kris JacobsCenter for Human Genetics, KU Leuven, Leuven, Belgium; Center for Cancer biology, VIB, Leuven, Belgium; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven.
David NittnerCenter for Cancer biology, VIB, Leuven.
Johan MaertensLeuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium; Department of Hematology, UZ Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven.
Heidi SegersLeuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Department of Pediatric Oncology, UZ Leuven, Leuven.
Jan CoolsCenter for Human Genetics, KU Leuven, Leuven, Belgium; Center for Cancer biology, VIB, Leuven, Belgium; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven. jan.cools@kuleuven.be.
KU Leuven · BEUniversitair Ziekenhuis Leuven · BEVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyloid Precursor Protein SecretasesAntineoplastic Combined Chemotherapy ProtocolsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaCell Line, TumorDexamethasoneHumansPresenilin-1T-LymphocytesAmyloid Precursor Protein SecretasesDexamethasonePresenilin-1PSEN1 protein, human

Identifiers

PMID36700404
PMCPMC10483366
OpenAlexW4318066523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.