Evidence map›Paper›PMID 36700346›Full record

ArticleThe British journal of psychiatry : the journal of mental science2023

Processing of social and monetary rewards in autism spectrum disorders.

Sarah Baumeister, Carolin Moessnang, Nico Bast, Sarah Hohmann, Pascal Aggensteiner, Anna Kaiser, Julian Tillmann, David Goyard, Tony Charman, Sara Ambrosino and 32 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Valence-Arousal Asymmetry: Rethinking Facial Emotion Recognition in Preschool Autism Through Eye-Tracking.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

42 authors at 15 institutions in 13 countries.

Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0001-9005-0084
Carolin MoessnangDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Nico BastDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany and Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goethe University, Frankfurt, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Pascal AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-1048-9044
Anna KaiserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Julian TillmannDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom and Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, Vienna, Austria.
David GoyardNeurospin Centre CEA, Saclay, Gif sur Yvette, France.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-1993-6549
Sara AmbrosinoDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
Simon Baron-CohenAutism Research Centre, Department of Psychiatry, University of Cambridge, UK.
Christian BeckmannDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
Sven BölteCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet and Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden and School of Allied Health, University of Western Australia, Perth, Western Australia.
Thomas BourgeronInstitut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.
Annika RauschDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
Daisy CrawleyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Flavio Dell'AcquaDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Guillaume DumasInstitut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.
Sarah DurstonDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
Christine EckerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goethe University, Frankfurt, Germany.
Dorothea L FlorisDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands and Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerland.
Vincent FrouinNeurospin Centre CEA, Saclay, Gif sur Yvette, France.
Hannah HaywardDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Rosemary HoltAutism Research Centre, Department of Psychiatry, University of Cambridge, UK.
Mark H JohnsonAutism Research Centre, Department of Psychiatry, University of Cambridge, UK and Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.
Emily J H JonesCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
Meng-Chuan LaiAutism Research Centre, Department of Psychiatry, University of Cambridge, UK; Centre for Addiction and Mental Health and The Hospital for Sick Children, Department of Psychiatry, University of Toronto, Canada and Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taiwan.
Michael V LombardoAutism Research Centre, Department of Psychiatry, University of Cambridge, UK and Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Italy.
Luke MasonCentre for Brain and Cognitive Development, Birkbeck, University of London, UK.
Bethany OakleyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Marianne OldehinkelDonders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, the Netherlands.
Antonio M PersicoChild and Adolescent Neuropsychiatry Program at Modena University Hospital, & Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.
Antonia San José CáceresDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón and CIBERSAM, Spain.
Thomas WolfersDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
Eva LothDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Declan G M MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Jan K BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands and Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, the Netherlands.
Heike TostDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0003-4595-1144
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital, University of Zurich, Zurich, Switzerland and Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
EU-AIMS LEAP Group
Heidelberg University · DEKing's College London · GBRadboud University Nijmegen · NLUniversity of Cambridge · GBBirkbeck, University of London · GBCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRGoethe University Frankfurt · DEInstitut Pasteur · FRUtrecht University · NLCentre for Addiction and Mental Health · CAItalian Institute of Technology · ITThe University of Western Australia · AUUniversity of Modena and Reggio Emilia · ITUniversity of Vienna · ATUniversity of Zurich · CH

Funding

Autism SpeaksMedical Research Council MR/T003057/1
6 · The paper itself

Abstract

backgroundReward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD.

aimsUtilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD.

methodFunctional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.6 years of age) and 181 typically developing participants (7.6-30.8 years of age).

resultsAcross social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses,

conclusionsOur results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAutistic DisorderBrainBrain MappingHumansMagnetic Resonance ImagingRewardADHD symptomsAutism spectrum disorderautism traitsfMRImultisitereward processing

Identifiers

PMID36700346
PMCPMC9929925
OpenAlexW4318169236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.