Evidence map›Paper›PMID 36700219›Full record

ArticleFrontiers in immunology2022

Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8

Arailym Sarsembayeva, Melanie Kienzl, Eva Gruden, Dusica Ristic, Kathrin Maitz, Paulina Valadez-Cosmes, Ana Santiso, Carina Hasenoehrl, Luka Brcic, Jörg Lindenmann and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Review
  5. LifelongNutrients · 2026
    Article
  6. Article
  7. [Cannabinoid receptor 2 inhibition on acantholysis in oral mucosal pemphigus].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
  8. Article
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  10. Article
  11. Review
  12. Article
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  14. Article
  15. Article
  16. Review
  17. GPCRs: emerging targets for novel T cell immune checkpoint therapy.Cancer immunology, immunotherapy : CII · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Arailym SarsembayevaDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Melanie KienzlDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Eva GrudenDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Dusica RisticDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Kathrin MaitzDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Paulina Valadez-CosmesDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Ana SantisoDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Carina HasenoehrlDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Luka BrcicDiagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Jörg LindenmannDivision of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
Julia KarglDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Rudolf SchichoDivision of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Medical University of Graz · ATBioTechMed-Graz · AT

Funding

Austrian Science Fund FWF KLI 887Austrian Science Fund FWF P 33325
6 · The paper itself

Abstract

Cannabinoid (CB) receptors (CB

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsReceptor, Cannabinoid, CB2AnimalsCarcinogenesisCD8-Positive T-LymphocytesHumansKiller Cells, NaturalMiceMice, KnockoutTumor MicroenvironmentCnr2 protein, mouseReceptor, Cannabinoid, CB2cannabinoid receptorsCB1CB2CD8+ T cellsimmunotherapyNK cellsnon-small cell lung cancertumor microenvironment

Identifiers

PMID36700219
PMCPMC9868666
OpenAlexW4313894762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.