Evidence map›Paper›PMID 36700204›Full record

ArticleFrontiers in immunology2022

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C M van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J I Catsman, Iris N Pardieck, Maaike Kreft and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Aldo SpanjaardDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Maria StratigopoulouDepartment of Pathology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Lymphoma and Myeloma center Amsterdam (LYMMCARE), Amsterdam, Netherlands.
Daniël de GrootDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Muhammad AslamDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Paul C M van den BerkDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Chantal StappenbeltDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Matilda AyidahDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Joyce J I CatsmanDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Iris N PardieckDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Maaike KreftDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Ramon ArensDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Jeroen E J GuikemaDepartment of Pathology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Lymphoma and Myeloma center Amsterdam (LYMMCARE), Amsterdam, Netherlands.
Heinz JacobsDivision of Tumor Biology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
The Netherlands Cancer Institute · NLOncode Institute · NLAmsterdam University Medical Centers · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (

Indexed as

Immunoglobulin Class SwitchingSomatic Hypermutation, ImmunoglobulinB-LymphocytesCell DifferentiationDNA RepairB-cellclass switch recombinationdevelopmenthomeostasisHUWE1immune responsessomatic hypermutation

Identifiers

PMID36700204
PMCPMC9869049
OpenAlexW4315490832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.