ArticleBiochemistry and biophysics reports2023
Effects of succinic acid on dermal fibroblasts during cultivation under extremely hypoxic conditions.
Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Refractory Stasis Dermatitis Due to Chronic Venous Insufficiency With Psychosocial Worsening in 2 Septuagenarian Patients Treated With Hyaluronic Acid-Succinic Acid Intradermotherapy.The American journal of case reports · 2026Article
- The PATH Protocol for Integrated Facial Rejuvenation: A Preliminary Three-Patient Case Report Series and Narrative Review of the Literature.Reports (MDPI) · 2026Article
- Hyaluronic Acid, Succinic Acid, and Exosomes in the Treatment of Facial Hyperpigmentation: A Report of Two Cases.Cureus · 2026Article
- Efficacy and Effectiveness of High Molecular Weight Non-Cross-Linked Hyaluronic Acid Plus Succinic Acid Mesotherapy in Rosacea as Adjunct Therapy.Journal of cosmetic dermatology · 2025Article
- Hyaluronic and Succinic Acid: New Biostimulating Combination to Counteract Dermal and Subcutaneous Aging.International journal of molecular sciences · 2025Article
- Multiomics provides insights into dynamic changes of aromatic profile during flue-curing process in tobacco (Nicotiana tabacum L.) leaves.BMC plant biology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Succinate is one of the most important raw materials in the energy-producing cycle, enabling a 'shortcut' route for ATP production via oxidative metabolism. Fumarate is produced from succinate by the oxygen-dependent succinate dehydrogenase. In this study we investigated the influence of different succinic acid concentrations on the process of cellular senescence under normal and hypoxic conditions. The most promising doses were chosen by using a cell viability test (0.2-1.5 mM). After the long-term cultivation it was shown that there was no significant difference in senescence β-galactosidase expression between samples with variable concentrations of succinate. Despite this fact, large differences in expression levels of senescence and pluripotency markers were found between the samples depending on the oxygen level and concentration of succinic acid.
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Registered trials
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