Evidence map›Paper›PMID 36700122›Full record

ArticleMolecular therapy. Methods & clinical development2023

Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background.

Geoffrey D Keeler, Cristina D Gaddie, Addelynn S Sagadevan, Kevin G Senior, Isabelle Côté, Michaela Rechdan, Daniel Min, David Mahan, Bianca Poma, Brad E Hoffman

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Truncated complement factor H Y402 gene therapy rescues C3 glomerulonephritis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Geoffrey D KeelerDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Cristina D GaddieDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Addelynn S SagadevanDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kevin G SeniorDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Isabelle CôtéDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Michaela RechdanDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Daniel MinDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
David MahanDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Bianca PomaDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Brad E HoffmanDepartment of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
University of Florida · US

Funding

Restoring Immune Tolerance in a Model of Multiple SclerosisR01AI128074 · NIAID · UNIVERSITY OF FLORIDA · PI Geoffrey D Keeler · 2017 to 2026
$3.7M
NIAID NIH HHS R01 AI128074
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AAVadeno-associated virusautoimmune diseaseautoimmunityEAEgene therapyimmune toleranceimmunotherapymultiple sclerosisregulatory T cellsTregs

Identifiers

PMID36700122
PMCPMC9849872
OpenAlexW4313252356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.