Evidence map›Paper›PMID 36700043›Full record

ArticleMolecular therapy. Nucleic acids2023

Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma.

Yanhong Zhang, Rosalia Rabinovsky, Zhiyun Wei, Rachid El Fatimy, Evgeny Deforzh, Bai Luan, Leonid Peshkin, Erik J Uhlmann, Anna M Krichevsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yanhong ZhangDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Rosalia RabinovskyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Zhiyun WeiDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Rachid El FatimyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Evgeny DeforzhDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Bai LuanDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Leonid PeshkinDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Erik J UhlmannDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Anna M KrichevskyDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Initiative for RNA Medicine, Boston, MA 02115, USA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Reverse Engineering of Cell SenescenceR01AG073341 · NIA · HARVARD MEDICAL SCHOOL · PI MARC Wallace KIRSCHNER · 2022 to 2026
$3.3M
Epigenetics and 3D Structure of miR-10b/HoxD Locus in the Brain and Malignant GliomaR01NS113929 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KRICHEVSKY, ANNA M. · 2020 to 2024
$3.1M
Developing miR-10b targeting for glioblastomaR01CA215072 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KRICHEVSKY, ANNA M. · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA215072NIA NIH HHS R01 AG073341NINDS NIH HHS R01 NS113929
6 · The paper itself

Abstract

MicroRNA-10b (miR-10b) is an essential glioma driver and one of the top candidates for targeted therapies for glioblastoma and other cancers. This unique miRNA controls glioma cell cycle and viability via an array of established conventional and unconventional mechanisms. Previously reported CRISPR-Cas9-mediated miR-10b gene editing of glioma cells

Indexed as

bystander effectgene editingglioblastomaIGFBP2miR-10bMT: Non-coding RNAsPGK1

Identifiers

PMID36700043
PMCPMC9852814
OpenAlexW4313530315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.