ArticleFrontiers in behavioral neuroscience2022
Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress.
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 18 citations in OpenAlex.
- Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Connectivity patterns in the DMN that are impacted by traumatic stress.Research square · 2026Article
- Estrous cycle stage gates the effect of stress on reward learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Using in vivo MRI to reveal circuits that are sensitive to traumatic stress in male and female rats.Neuropharmacology · 2025Article
- Is the Relationship Between Adolescent Social Isolation and Anxiety-Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?Brain and behavior · 2025Article
- Proteomic insights into extinction memory deficits in stress-susceptible female rats.Frontiers in behavioral neuroscience · 2025Article
- Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury.Journal of neuroinflammation · 2024Article
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.Neuroscience and biobehavioral reviews · 2024Review
- Antagonism of the brain P2X7 ion channel attenuates repeated social defeat induced microglia reactivity, monocyte recruitment and anxiety-like behavior in male mice.Brain, behavior, and immunity · 2024Article
- Sex-dependent effects of angiotensin II type 1 receptor blocker on molecular and behavioral changes induced by single prolonged stress.Behavioural brain research · 2023Article
- Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397.Journal of anatomy · 2023Article
- The role of avoidance in modulating single prolonged stress effects on emotional memory in male and female rats.Behavioural brain research · 2023Article
- Purinergic P2X7 receptor-mediated inflammation precedes PTSD-related behaviors in rats.Brain, behavior, and immunity · 2023Article
- Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific.International journal of molecular sciences · 2023Article
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6 authors at 2 institutions in 1 country.
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Abstract
Single prolonged stress (SPS) is a preclinical rodent model for studying post-traumatic stress disorder (PTSD)-like behaviors. Previously we found that increased expression of the microglial marker Iba-1 in the ventral hippocampus after SPS exposure was associated with impaired fear extinction, suggesting that microglial activity contributed to the SPS-induced behavioral changes. To test this, we examined whether reducing microglia with the colony-stimulating factor 1 receptor blocker, PLX3397, in the diet would prevent the SPS-induced extinction impairment. Male rats exposed to SPS showed enhanced fear acquisition and impaired fear extinction memory. Adding PLX3397 to the diet prevented these behavioral changes. In contrast, PLX3397 did not prevent SPS from impairing fear extinction memory in the female rats. Despite the sex-dependent behavioral effects, we found a reduced number and area fraction of Iba-1+ microglia in both male and female rats suggesting that PLX3397 had similar effects on microglia in both sexes. Altogether, these results suggest that microglia contribute to the behavioral changes induced by SPS in male but not female rats.
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