ArticleFrontiers in neuroscience2022
Changes in the structure, perfusion, and function of the hippocampus in type 2 diabetes mellitus.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes.Nutrition & diabetes · 2025Trial
- Progressive modeling of multiscale hippocampal subfield structural representation improves the prediction performance of mild cognitive impairment in type 2 diabetes.European archives of psychiatry and clinical neuroscience · 2026Article
- Neurovascular uncoupling in type 2 diabetes mellitus: multimodal MRI reveals the association between hippocampal and subcortical structures dysfunction and cognitive decline.Frontiers in neurology · 2026Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
- Analysis of ALPS-Index: Difference in Type 2 Diabetes Mellitus With or Without Mild Cognitive Impairment and Its Relationship With Hippocampal Microstructure.Brain and behavior · 2025Article
- The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes-A Perspective from Psychoneuroimmunology.Biomedicines · 2024Review
- Urine Albumin-to-Creatinine Ratio as an Indicator of Brain Activity Changes in Chronic Kidney Disease: A Resting-State fMRI Study.Brain and behavior · 2024Article
- Intranasal insulin effect on cognitive and/or memory impairment: a systematic review and meta-analysis.Cognitive neurodynamics · 2024Review
- White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance.Scientific reports · 2024Article
- Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline.Frontiers in psychiatry · 2024Article
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Authors and funding
8 authors.
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Abstract
Objective: This study aims to explore the changes in the structure, perfusion, and function of the bilateral hippocampus in type 2 diabetes mellitus (T2DM) applying multimodal MRI methods, hoping to provide reliable neuroimaging evidence for the diagnosis of hippocampus-related brain injury in T2DM. Methods: We recruited 30 T2DM patients and 45 healthy controls (HCs), on which we performed 3D T1-weighted images, resting-state functional MRI (rs-fMRI), arterial spin labeling (ASL) sequences, and a series of cognitive tests. Then, we compared the differences of two groups in the cerebral blood flow (CBF) value, amplitude of low-frequency fluctuation (ALFF) value, fractional ALFF (fALFF) value, coherence-based regional homogeneity (Cohe-ReHo) value, and degree centrality (DC) values of the bilateral hippocampus. Results: In the T2DM group, the bilateral hippocampal volumes and the CBF value of the right hippocampus were lower than those in the HCs, while the ALFF value, fALFF value, and Cohe-ReHo value of the bilateral hippocampus were higher than those in the HCs. Correlation analysis showed that fasting blood glucose (FBG) was negatively correlated with the residuals of left hippocampal volume ( Conclusion: This study indicated that the volume and perfusion of the hippocampus are decreased in T2DM patients that related to chronic hyperglycemia. Local spontaneous neural activity and coordination are increased in the hippocampus of T2DM patients, possibly as an adaptive compensation for cognitive decline.
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