ArticleBioinformatics advances2022
MAGI-MS: multiple seed-centric module discovery.
Article in Bioinformatics advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Summary: Complex disorders manifest by the interaction of multiple genetic and environmental factors. Through the construction of genetic modules that consist of highly coexpressed genes, it is possible to identify genes that participate in common biological pathways relevant to specific phenotypes. We have previously developed tools MAGI and MAGI-S for genetic module discovery by incorporating coexpression and protein interaction networks. Here, we introduce an extension to MAGI-S, denoted as Merging Affected Genes into Integrated Networks-Multiple Seeds (MAGI-MS), which permits the user to further specify a disease pathway of interest by selecting multiple seed genes likely to function in the same molecular mechanism. By providing MAGI-MS with seed genes involved in processes underlying certain classes of neurodevelopmental disorders, such as epilepsy, we demonstrate that MAGI-MS can reveal modules enriched in genes relevant to chemical synaptic transmission, glutamatergic synapse and other functions associated with the provided seed genes. Availability and implementation: MAGI-MS is free and available at https://github.com/jchow32/MAGI-MS. Supplementary information: Supplementary data are available at
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