ArticleFrontiers in veterinary science2022
Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats.
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Investigation of the protective effect of visnagin against cadmium toxicity in rat nephropathy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Renoprotective effects of curcumin in cats with chronic kidney disease.Journal of veterinary internal medicine · 2026Article
- Synergy of zinc oxide nanoparticles to losartan attenuates kidney injury induced by unilateral ureteral obstruction through modulation of the TNF-α/IL6 and BAX/BCL2 signaling pathways.International urology and nephrology · 2025Article
- Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification.BMC pharmacology & toxicology · 2025Article
- Unraveling TGF-β1's Role in Mediating Fibrosis and Cell Death in Feline Kidney Cells.Animals : an open access journal from MDPI · 2025Article
- Therapeutic Effects ofVeterinary sciences · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Chronic kidney disease (CKD) is a frequent condition in elderly cats. Bcl-2 is linked to kidney disease through the processes of apoptosis and fibrosis. The purpose of this study is to examine Bcl-2 levels in CKD and clinically healthy age-matched cats in order to evaluate the relationship between Bcl-2 levels, signalment, and blood parameters in cats with CKD. The circulating levels of Bcl-2 were determined using an immunoassay in twenty-four CKD cats and eleven clinically healthy age-matched cats by the utilization of the general linear model (GLM), Pearson correlation, principal component analysis (PCA), ROC curves, the Cox hazard model, and Kaplan-Meier survival analysis. These were all conducted in order to explore Bcl-2 levels and their connection with other variables. The Bcl-2 immunohistochemical intensity was graded in each glomerulus and tubulointerstitium. McNemar's test was performed in order to compare the expression of Bcl-2 in the two renal tissue sites. The circulating Bcl-2 of CKD cats was significantly lower than those of clinically healthy age-matched cats (
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