Evidence map›Paper›PMID 36699314›Full record

ArticleFrontiers in pediatrics2022

Neurofilament Light Chain serum levels after Hypoxia-Ischemia in a newborn piglet model.

Kasper Jacobsen Kyng, Sven Wellmann, Verena Lehnerer, Lærke Hjøllund Hansen, Jens Kuhle, Tine Brink Henriksen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07292220 (Investigation of Neurofilament Light Chain), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07292220 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Investigation of Neurofilament Light Chain (NfL) Levels in Newborns Diagnosed With Hypoxic Ischemic Encephalopathy: A Case-Control Study

Typeobservational_patient_registrySponsorMustafa GürkanRan2025 to 2026Enrolled20ConditionsHypoxic-Ischemic Encephalopathy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Kasper Jacobsen KyngAarhus University Hospital and Aarhus University, Department of Pediatrics and Adolescent Medicine and Department of Clinical Medicine, Aarhus, Denmark.
Sven WellmannDepartment of Neonatology, University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.
Verena LehnererDepartment of Neonatology, University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.
Lærke Hjøllund HansenAarhus University Hospital and Aarhus University, Department of Pediatrics and Adolescent Medicine and Department of Clinical Medicine, Aarhus, Denmark.
Jens KuhleNeurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Tine Brink HenriksenAarhus University Hospital and Aarhus University, Department of Pediatrics and Adolescent Medicine and Department of Clinical Medicine, Aarhus, Denmark.
Aarhus University Hospital · DKUniversity of Regensburg · DEUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Neurofilament light Chain (NfL) is a promising brain injury biomarker which may assist diagnosis and prognostication in hypoxic-ischemic encephalopathy (HIE). The aim of this study was to investigate serum NfL levels after hypoxia-ischemia (HI) in a newborn piglet model. Second, to characterize the influence of sex, weight, and treatment with remote ischemic postconditioning (RIPC) on NfL and the correlation between NfL, brain imaging and histologic brain injury. Methods: We used serum from 48 newborn piglets of both sexes subjected to 45 min of global HI, and 4 sham piglets. Blood was collected pre-HI, 2 h post-HI and 72 h post-HI. NfL was measured by single-molecule array (Simoa™). We analysed the temporal profile of NfL after HI, and correlations between NfL, magnetic resonance spectroscopy brain Lac/NAA ratios and histologic brain injury 72 h after HI. Results: Median (IQR) NfL levels were: pre-HI: 66 pg/ml (45-87), 2 h post-HI: 105 pg/ml (77-140), and 72 h post-HI: 380 pg/ml (202-552). The increase in NfL after HI was statistically significant ( Conclusion: NfL increased after HI, with the largest values at 72 h post-HI. Early NfL was sensitive but not very specific, whereas NfL at 72 h was both highly sensitive and specific for exposure to moderate-severe HI in this model of HI-induced brain injury. This was supported by a moderate correlation of NfL at 72 h with brain Lac/NAA ratio and histopathology.

Indexed as

animal modelbiomarkerhypoxia-ischemiahypoxic-ischemic encephalopathynewborn brain injuryNfL

Identifiers

PMID36699314
PMCPMC9869944
OpenAlexW4315477866

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.