Evidence map›Paper›PMID 36699281›Full record

ArticleHeliyon2023

Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite.

Shubha R L Malla, Archana Gujjari, Carlos E Corona, Gary W Beall, L Kevin Lewis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shubha R L MallaMaterials Science, Engineering and Commercialization Program, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Archana GujjariMaterials Science, Engineering and Commercialization Program, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Carlos E CoronaDepartment of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Gary W BeallMaterials Science, Engineering and Commercialization Program, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
L Kevin LewisMaterials Science, Engineering and Commercialization Program, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Texas State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Halloysite particles (HNTs) are naturally occurring aluminosilicate nanotubes of low toxicity that have shown great promise for drug and biomolecule delivery into human and animal cells. Kaolinite particles retain the same layered structure as HNT, but do not form nanotubes. In this study, the spectrophotometric and sedimentation properties of the two clays in aqueous solutions and their abilities to associate with both small and large nucleic acids have been investigated. Both clays scattered ultraviolet light strongly and this characteristic of HNT was not affected by either vacuum treatment to remove trapped gases or by sonication. Vacuum treatment increased the binding of small nucleic acids to HNT and this association was further enhanced by addition of divalent metal ions. By contrast, only small RNAs were bound efficiently by kaolinite in the presence of Mg

Indexed as

Drug deliveryGene deliveryGene therapyNanoclayNanotubeNonviral vectors

Identifiers

PMID36699281
PMCPMC9868539
OpenAlexW4316506215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.