ArticleCritical care explorations2023
Overt and Occult Hypoxemia in Patients Hospitalized With COVID-19.
Article in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Triaging acute chest syndrome clinical decision-making using bedside SaO2/FiO2 ratio.Blood advances · 2025Observational
- Kinematic signature of high risk labored breathing revealed by novel signal analysis.Scientific reports · 2024Article
- Dynamic prediction of hypoxemia risk at different time points based on preoperative and intraoperative features: machine learning applications in outpatients undergoing esophagogastroduodenoscopy.Annals of medicine · 2023Article
- Signatures of illness in children requiring unplanned intubation in the pediatric intensive care unit: A retrospective cohort machine-learning study.Frontiers in pediatrics · 2022Article
- Pulse Oximetry and Arterial Blood Gas Agreement in an Outpatient Black Lung Clinic: Implications for Clinical Assessment and Decision Making.Journal of primary care & community healthArticle
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15 authors.
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Abstract
Progressive hypoxemia is the predominant mode of deterioration in COVID-19. Among hypoxemia measures, the ratio of the Pao
objectivesMeasure overt and occult hypoxemia using ePFR. DESIGN SETTING AND
participantsWe retrospectively studied COVID-19 hospital encounters ( MAIN OUTCOMES AND MEASURES: We measured primary outcomes (death or ICU transfer within 24 hr), ePFR, conventional hypoxemia measures, baseline predictors (age, sex, race, comorbidity), and acute predictors (National Early Warning Score [NEWS] and Sequential Organ Failure Assessment [SOFA]). We updated predictors every 15 minutes. We assessed predictive validity using adjusted odds ratios (AORs) and area under the receiver operating characteristic curves (AUROCs). We quantified disparities (Black vs non-Black) in empirical cumulative distributions using the Kolmogorov-Smirnov (K-S) two-sample test.
resultsOvert hypoxemia (low ePFR) predicted bad outcomes (AOR for a 100-point ePFR drop: 2.7 [UVA]; 1.7 [Emory]; CONCLUSIONS AND RELEVANCE: The ePFR was a valid measure of overt hypoxemia. In COVID-19, it may outperform multi-organ dysfunction models. By accounting for biased oximetry as well as clinicians' real-time responses to it (supplemental oxygen adjustment), ePFRs may reveal racial disparities attributable to occult hypoxemia.
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