ArticlePlastic and reconstructive surgery. Global open2023
Analysis of 5-year Mortality following Lower Extremity Amputation due to Vascular Disease.
Article in Plastic and reconstructive surgery. Global open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Epidemiology and Outcome of Diabetic Foot Ulcers in Nigeria: A Systematic Review and meta-analysis of 2 Decades: 2005 - 2024.Journal of epidemiology and global health · 2026Pooled it
- The Barriers and Facilitators Healthcare Professionals' Experience When Assessing the Cutaneous Manifestations of Chronic Venous Insufficiency and Peripheral Arterial Disease in People With Dark Skin Tones: A Qualitative Descriptive Study.International wound journal · 2026Article
- Lower limb prosthesis abandonment and recycling of used components in the public healthcare sector of the Eastern Cape Province of South Africa.Canadian prosthetics & orthotics journal · 2026Article
- Deep learning-derived retinal biomarker associated with diabetes-related amputation in type 2 diabetes.Frontiers in endocrinology · 2026Observational
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- Article
- Clinical Severity and Systemic Inflammatory Indices as Predictors of In-Hospital Mortality After Limb Amputation a Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Understanding Functional and Hemodynamic Outcomes Across Lower Extremity Amputation Levels.Plastic and reconstructive surgery. Global open · 2025Article
- Article
- Post-below-knee amputation venous thromboembolism and mortality in United States veterans.Research and practice in thrombosis and haemostasis · 2025Article
- Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.Clinical epidemiology · 2025Article
- Using machine learning models to predict post-revascularization thrombosis in PAD.Frontiers in artificial intelligence · 2025Article
- Possibilities for revascularization and closure of wound defects in lower limbs with critical ischemia through free gracilis flap transfer: review of 3 cases.Jornal vascular brasileiro · 2025Article
- Quantification of the Survival Disadvantage Associated with Major Amputation in Patients with Peripheral Arterial Disease.Journal of clinical medicine · 2024Article
- The Incidence and Outcomes of Major Limb Amputation in New Zealand from 2010 to 2021.Journal of clinical medicine · 2024Article
- Survival rate of diabetic-related lower extremity amputees in hospitals in the Eastern Cape.African journal of disability · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mortality rates following major lower extremity amputations (LEAs) 30 days-365 days postoperative have decreased, but 5-year rates remain high at 40.4%-70%. These data may not reflect recent advances in peripheral arterial disease (PAD) care, and comorbidities of chronic PAD may lead to mortality more frequently than the amputation itself. Mortality rates between diabetic and nondiabetic patients were also analyzed. Methods: The California Office of Statewide Health Planning and Development hospital database was queried for patients admitted January 1, 2007-December 31, 2018. ICD-9-CM codes identified patients with vascular disease and an amputation procedure. Results: There were 26,669 patients. The 30-day, 90-day, 1-year, and 5-year major LEA mortality rates were 4.82%, 8.62%, 12.47%, and 18.11%, respectively. Weighted averages of 30-day, 90-day, 1-year, and 5-year major LEA mortality rates in the literature are 13%, 15.40%, 47.93%, and 60.60%, respectively. Mortality risk associated with vascular disease after amputation (hazard ratio = 22.07) was 11 times greater than risk associated with amputation-specific complications from impaired mobility (hazard ratio = 1.90; Conclusions: This study suggests that people may be living longer after their major LEA than was previously thought. This study suggests that patients' PAD may play a bigger role in contributing to their mortality than complications from loss of mobility postamputation. Although having diabetes was associated with lower postamputation mortality, the difference was no longer significant by 5 years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.