Evidence map›Paper›PMID 36699047›Full record

ReviewFrontiers in endocrinology2022

Nitric oxide and thyroid carcinoma: A review.

Yu Huang, Rinkiko Suguro, Wei Hu, Jiayu Zheng, Yawen Liu, Mingxin Guan, Na Zhou, Xin Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. International journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yu HuangSchool of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.
Rinkiko SuguroState Key Laboratory of Quality Research in Chinese Medicine, Macau, Macau SAR, China.
Wei HuState Key Laboratory of Quality Research in Chinese Medicine, Macau, Macau SAR, China.
Jiayu ZhengSchool of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.
Yawen LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Mingxin GuanCollege of Pharmacy, Dalian Medical University, Dalian, China.
Na ZhouSchool of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.
Xin ZhangSchool of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.
Macau University of Science and Technology · MODalian Medical University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid carcinoma is the most common endocrine cancer in the world, and its incidence has been steadily increasing in recent years. Despite its relatively good prognosis, therapies have not improved greatly in recent years. Therefore, exploring new therapies for thyroid carcinoma represents an unmet need. Nitric oxide (NO) is a short-term endogenous signaling molecule that plays a vital role in various physiological and pathological processes and is synthesized by nitric oxide synthase (NOS). Many studies have been conducted over the past decades to explain its correlation to cancer. NO exerts a wide range of effects on cancer, involving angiogenesis, apoptosis, cell cycle, invasion, and metastasis. It also serves a dual function by promoting and halting tumor development simultaneously. The relationship between NO and thyroid carcinoma has been intensively studied and discussed. This paper reviews the role and molecular mechanism of NO in thyroid carcinoma and discusses potentials of prevention and treatment of thyroid carcinoma.

Indexed as

Nitric OxideThyroid NeoplasmsApoptosisHumansNitric Oxide SynthaseSignal TransductionNitric OxideNitric Oxide Synthaseeitric oxide synthaseendocrine systemnitric oxidethyroid carcinomatreatment

Identifiers

PMID36699047
PMCPMC9870175
OpenAlexW4313827972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.