ArticleFrontiers in endocrinology2022
GVBD rate is an independent predictor for pregnancy in ICSI patients with surplus immature oocytes.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Germinal vesicle oocytes' rescue: a worthless treatment or a patient-centred approach? Eight years of clinical experience in poor prognosis patients.Human reproduction (Oxford, England) · 2026Article
- Loss of DLGAP5 impairs human and mouse oocyte maturation via disrupting the PI3K-AKT signaling axis.Journal of ovarian research · 2026Article
- First follicular fluid cf-mtDNA sequencing unveils ovarian stimulation-induced mutations impacting oocyte quality and IVF success.Journal of assisted reproduction and genetics · 2025Article
- In Vitro Maturation and Time-Lapse Imaging of Immature Human Oocytes: A Direction Toward Clinical Applications.Methods in molecular biology (Clifton, N.J.) · 2025Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Introduction: It was reported that there were still up to 30% immature retrieved oocyte at germinal vesicle (GV) or metaphase I (MI) stage. Whether the spontaneous maturity competency of immature oocytes associated to the clinical outcome of Methods: This retrospective cohort study included couples undergoing ICSI in a university-affiliated hospital. Surplus immature oocytes during ICSI were collected and cultured Results: A total of 191 couples were included with an overall GVBD rate of 63.7% (327/513) and oocyte maturation rate of 46.8% (240/513). 53.4% (102/191) of them had embryos transferred freshly, which originated from metaphase II oocytes that matured spontaneously Conclusion: In conclusion, GVBD rate and progesterone level on HCG day may be associated with pregnancy outcomes in infertile couples during the regular ICSI procedure. An elevated GVBD rate within 24 h may greatly increase the likelihood of pregnancy in infertile couples during ICSI. This preliminary study may optimize clinical pregnancy prediction, which provides support in decision-making in clinical practice.
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