Evidence map›Paper›PMID 36699012›Full record

ArticleFrontiers in cell and developmental biology2022

The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut.

Frederik Paulussen, Chetan P Kulkarni, Frank Stolz, Eveline Lescrinier, Stijn De Graeve, Suzan Lambin, Arnaud Marchand, Patrick Chaltin, Peter In't Veld, Joseph Mebis and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Sympathetic denervation alters pulmonary microbiota diversity and composition in mice.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  3. Glucose sensing and homeostasis by adipocyte GPCR.Frontiers in endocrinology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Frederik PaulussenCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Chetan P KulkarniCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Frank StolzCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Eveline LescrinierMedicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Stijn De GraeveCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Suzan LambinCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Arnaud MarchandLeuven Research & Development, Leuven, Belgium.
Patrick ChaltinLeuven Research & Development, Leuven, Belgium.
Peter In't VeldDepartment of Pathology, Free University of Brussels, Brussels, Belgium.
Joseph MebisDepartment of Pathology, KU Leuven, Flanders, Belgium.
Jan TavernierDepartment of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Patrick Van DijckCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
Walter LuytenFunctional Genomics and Proteomics Research Unit, Department of Biology, KU Leuven, Leuven, Belgium.
Johan M TheveleinCenter for Microbiology, VIB, Leuven-Heverlee, Belgium.
KU Leuven · BEVIB-KU Leuven Center for Microbiology · BERega Institute for Medical Research · BEVIB-UGent Center for Medical Biotechnology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of sugar in the gut causes induction of SGLT1, the sodium/glucose cotransporter in intestinal epithelial cells (enterocytes), and this is accompanied by stimulation of sugar absorption. Sugar sensing was suggested to involve a G-protein coupled receptor and cAMP - protein kinase A signalling, but the sugar receptor has remained unknown. We show strong expression and co-localization with SGLT1 of the β2-adrenergic receptor (

Indexed as

Beta2-adrenergic receptorbeta2-adrenergic receptor antagonistsenterocytesglucose sensingglucose transportgutSGLT1

Identifiers

PMID36699012
PMCPMC9869975
OpenAlexW4315480674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.