Evidence map›Paper›PMID 36699001›Full record

ArticleMovement disorders clinical practice2023

Gender Differences in the Prevalence of Parkinson's Disease.

Alexandra Zirra, Shilpa C Rao, Jonathan Bestwick, Rajasumi Rajalingam, Connie Marras, Cornelis Blauwendraat, Ignacio F Mata, Alastair J Noyce

Abstract read
In one paragraph

Article in Movement disorders clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  14. The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Differentiating between the impact of sex and gender in Parkinson's disease: utilising these to advance current understanding and care practices.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  17. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandra ZirraPreventive Neurology Unit Wolfson Institute of Population Health, Queen Mary University of London London United Kingdom.
Shilpa C RaoGenomic Medicine Institute Lerner Research Institute, Cleveland Clinic Foundation Cleveland Ohio USA.ORCID https://orcid.org/0000-0002-2284-9203
Jonathan BestwickPreventive Neurology Unit Wolfson Institute of Population Health, Queen Mary University of London London United Kingdom.
Rajasumi RajalingamUniversity Health Network University of Toronto Toronto Ontario Canada.
Connie MarrasUniversity Health Network University of Toronto Toronto Ontario Canada.
Cornelis BlauwendraatLaboratory of Neurogenetics, National Institute of Aging National Institutes of Health Bethesda Maryland USA.
Ignacio F MataGenomic Medicine Institute Lerner Research Institute, Cleveland Clinic Foundation Cleveland Ohio USA.
Alastair J NoycePreventive Neurology Unit Wolfson Institute of Population Health, Queen Mary University of London London United Kingdom.ORCID https://orcid.org/0000-0003-3027-5497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. Objective: The objective of this systematic review and meta-analysis was to update the overall male/female prevalence ratios (OPR). Methods: We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. Results: We included 19 new articles and 13 articles from a previously published meta-analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. Conclusion: Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence.

Indexed as

gender differences.meta‐analysisParkinson's diseaseprevalencesystematic review

Identifiers

PMID36699001
PMCPMC9847309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.