Evidence map›Paper›PMID 36698965›Full record

ArticleComputational and structural biotechnology journal2023

EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier.

O V Semyachkina-Glushkovskaya, A S Karavaev, M D Prokhorov, A E Runnova, E I Borovkova, Ishbulatov Yu M, A N Hramkov, D D Kulminskiy, N I Semenova, K S Sergeev and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 2 countries.

O V Semyachkina-GlushkovskayaPhysics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
A S KaravaevCharité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
M D ProkhorovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A E RunnovaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
E I BorovkovaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
Ishbulatov Yu MSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A N HramkovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
D D KulminskiySaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
N I SemenovaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
K S SergeevSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A V SlepnevSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
Sitnikova E YuSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
M O ZhuravlevSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
I V FedosovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A A ShirokovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
I A BlokhinaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A I DubrovskiSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A V TerskovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A P KhorovodovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
V B AgeevSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
D A ElovenkoSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
A S EvsukovaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
V V AdushkinaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
V V TelnovaSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
D E PostnovSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
T U PenzelSaratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia.
J G KurthsPhysics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
Saratov State University · RUSaratov State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lymphatic drainage system of the brain (LDSB) is the removal of metabolites and wastes from its tissues. A dysfunction of LDSB is an important sign of aging, brain oncology, the Alzheimer's and Parkinson's diseases. The development of new strategies for diagnosis of LDSB injuries can improve prevention of age-related cerebral amyloid angiopathy, neurodegenerative and cerebrovascular diseases. There are two conditions, such as deep sleep and opening of the blood-brain-barrier (OBBB) associated with the LDSB activation. A promising candidate for measurement of LDSB could be electroencephalography (EEG). In this pilot study on rats, we tested the hypothesis, whether deep sleep and OBBB can be an informative platform for an effective extracting of information about the LDSB functions. Using the nonlinear analysis of EEG dynamics and machine learning technology, we discovered that the LDSB activation during OBBB and sleep is associated with similar changes in the EEG θ-activity. The OBBB causes the higher LDSB activation vs. sleep that is accompanied by specific changes in the low frequency EEG activity extracted by the power spectra analysis of the EEG dynamics combined with the coherence function. Thus, our findings demonstrate a link between neural activity associated with the LDSB activation during sleep and OBBB that is an important informative platform for extraction of the EEG-biomarkers of the LDSB activity. These results open new perspectives for the development of technology for the LDSB diagnostics that would open a novel era in the prognosis of brain diseases caused by the LDSB disorders, including OBBB.

Indexed as

ElectroencephalographyLymphatic drainage system of the brainMachine learning methodsNon-linear analysisOpening of the blood-brain barrierSleep

Identifiers

PMID36698965
PMCPMC9841170
OpenAlexW4311599644

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.