Evidence map›Paper›PMID 36698527›Full record

ArticleClinical case reports2023

Vaccine-induced immune thrombotic thrombocytopenia (VITT) after SARS-CoV-2 vaccination: Two cases from Germany with unusual presentation.

Rhea Edmonds, Linda Schönborn, Sunke Habben, Maria Paparoupa, Andreas Greinacher, Frank Schuppert

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rhea EdmondsDepartment of Gastroenterology, Endocrinology, Diabetology and General Medicine Klinikum Kassel Kassel Germany.ORCID https://orcid.org/0000-0002-3864-9361
Linda SchönbornDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine University of Greifswald Greifswald Germany.
Sunke HabbenDepartment of Gastroenterology, Endocrinology, Diabetology and General Medicine Klinikum Kassel Kassel Germany.
Maria PaparoupaDepartment of Intensive Care Medicine University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID https://orcid.org/0000-0003-1713-6759
Andreas GreinacherDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine University of Greifswald Greifswald Germany.
Frank SchuppertDepartment of Gastroenterology, Endocrinology, Diabetology and General Medicine Klinikum Kassel Kassel Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare clinical condition that has emerged during the mass immunization against SARS-CoV-2. Reports indicate that VITT may also be induced by other vaccines, such as the human papillomavirus vaccine, or occur independently of vaccination. Its recognition requires a high index of suspicion, especially in patients presenting with thrombocytopenia and thrombosis several days after vaccination with an adenoviral vector-based vaccine against SARS-CoV-2. Bleeding manifestations do not exclude VITT, as initially assumed. It is of great importance to perform the appropriate diagnostic tests early in the course of the disease, as false-negative results may occur and many aspects of VITT are not fully understood. These two cases from Germany demonstrate unusual presentations of VITT.

Indexed as

COVID‐19SARS‐CoV‐2 vaccinationvaccine‐induced immune thrombocytopenia and thrombosis

Identifiers

PMID36698527
PMCPMC9859986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.