ReviewFrontiers in nutrition2022
Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.
Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.Nutrients · 2025Pooled it
- Association Between Circulating Zinc and Risk for Childhood Asthma and Wheezing: A Meta-analysis on 21 Articles and 2205 Children.Biological trace element research · 2024Pooled it
- The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis.International archives of allergy and immunology · 2024Pooled it
- Micronutrients in Pediatric Asthma: Biological Mechanisms and Clinical Evidence-A Narrative Review.Nutrients · 2026Review
- Food introduction during the first year of life in a Swedish birth cohort - associations with allergy at 6 years of age.Nutrition journal · 2026Observational
- The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma.Pediatric discovery · 2026Review
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort.Health science reports · 2026Article
- Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies.International journal of molecular sciences · 2026Review
- Dietary zinc intake, serum zinc concentrations, and disease activity in children with juvenile idiopathic arthritis: a case-control study.Frontiers in nutrition · 2026Article
- Dietary approaches in dermatological disorders: mechanisms and clinical relevance.Postepy dermatologii i alergologii · 2026Review
- Geographic variation in lack of food group consumption among children in India: An analysis of change across 720 districts, 2016-2021.PLOS global public health · 2026Article
- Feeding the Skin Barrier: The Impact of Macro- and Micronutrients on Skin Barrier Function.Clinical and translational allergy · 2025Review
- Nutraceuticals Against Oxidative Stress in Allergic Diseases.Biomolecules · 2025Review
- The Role of Zinc in Pediatric Asthma and Allergic Rhinitis: Mechanisms and Clinical Implications.Nutrients · 2025Review
- Iron bioaccessibility in raw and cooked foods in vitro using fecal inocula from children and adults.Food chemistry: X · 2025Article
- Dietary Zn-Recent Advances in Studies on Its Bioaccessibility and Bioavailability.Molecules (Basel, Switzerland) · 2025Review
- Exploring management of acrodermatitis.Asia Pacific journal of clinical nutrition · 2025Article
- Nutritional Deficiencies and Management in Tuberculosis: Pharmacotherapeutic and Clinical Implications.Nutrients · 2025Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micronutritional deficiencies are common in atopic children suffering from atopic dermatitis, food allergy, rhinitis, and asthma. A lack of iron, in particular, may impact immune activation with prolonged deficiencies of iron, zinc, vitamin A, and vitamin D associated with a Th2 signature, maturation of macrophages and dendritic cells (DCs), and the generation of IgE antibodies. In contrast, the sufficiency of these micronutrients establishes immune resilience, promotion of regulatory cells, and tolerance induction. As micronutritional deficiencies mimic an infection, the body's innate response is to limit access to these nutrients and also impede their dietary uptake. Here, we summarize our current understanding of the physiological function of iron, zinc, and vitamins A and D in relation to immune cells and the clinical consequences of deficiencies in these important nutrients, especially in the perinatal period. Improved dietary uptake of iron is achieved by vitamin C, vitamin A, and whey compounds, whereas zinc bioavailability improves through citrates and proteins. The addition of oil is essential for the dietary uptake of beta-carotene and vitamin D. As for vitamin D, the major source comes
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